{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:59:45Z","timestamp":1781585985053,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiologica Open"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Computerized tomography-guided transthoracic needle biopsy (CT-TTNB) plays an important role in the diagnostic work-up of lung lesions. The literature reports varying results on complication rates, severity of complications, and diagnostic yield.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate CT-TTNB as a radiological outpatient clinic procedure and explore diagnostic yield and complication rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Between January 2017 and October 2019, a total of 559 patients underwent CT-TTNB. Patient records and CT scans were retrospectively reviewed and patient characteristics, lesion characteristics, biopsy procedure, and per- and post-procedural complications, as well as pathological diagnosis, were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 559 patients included, 511 had biopsies performed. Thereby, 48 biopsies (8.6%) were discontinued because of patient compliance issues and\/or the occurrence of pneumothorax before the biopsy was performed. The overall pneumothorax rate was 49.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 275 of 559 patients). Insertion of a drainage catheter was needed in 85 of the 275 patients with pneumothorax. Parenchymal bleeding was seen in 26.5% of the patients and haemoptysis in 5.5%. No cases of bleeding or haemoptysis required intervention or admission. Small mean lesion size and increased distance from pleura to the lesion were associated with a higher occurrence of complications. A conclusive pathological diagnosis was obtained in 278 of 511 (54.4%) biopsies. No patients were re-admitted after the two-hour observational period in the radiological department.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CT-TTNB as an outpatient clinic procedure is feasible but has a moderate diagnostic yield and relatively high complication rates for minor complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20584601251326485","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T09:04:12Z","timestamp":1742461452000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic yield and complications of CT-guided biopsy of lung lesions as a radiological outpatient clinic procedure"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5782-0513","authenticated-orcid":false,"given":"Katrine Bitsch","family":"Johansen","sequence":"first","affiliation":[{"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Valtersson","sequence":"additional","affiliation":[{"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian B.","family":"Laursen","sequence":"additional","affiliation":[{"name":"Odense University Hospital"},{"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2119-5129","authenticated-orcid":false,"given":"Bo","family":"Mussmann","sequence":"additional","affiliation":[{"name":"University of Southern Denmark"},{"name":"Odense University Hospital, Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"University of Southern Denmark"},{"name":"Odense University Hospital, Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Graumann","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-3635","authenticated-orcid":false,"given":"Pia Iben","family":"Pietersen","sequence":"additional","affiliation":[{"name":"University of Southern Denmark"},{"name":"Odense University Hospital, Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"45","article-title":"Epidemiology of lung cancer","volume":"25","author":"Thandra KC","year":"2021","unstructured":"Thandra KC, Barsouk A, Saginala K, et al. 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