{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:53:19Z","timestamp":1793944399047,"version":"4.8.0"},"reference-count":5,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Beijing Natural Science Foundation of China","award":["7152053"],"award-info":[{"award-number":["7152053"]}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support","doi-asserted-by":"crossref","award":["ZY201404"],"award-info":[{"award-number":["ZY201404"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700287"],"award-info":[{"award-number":["81700287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Science and Technology Project \u201cThe Capital characteristic Clinical Application Research\u201d","award":["Z141107002514130"],"award-info":[{"award-number":["Z141107002514130"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>Thrombotic storm (TS) is a rare disease, especially with thrombus in the heart of pediatric patient. We present a case of a 4-year-old boy, who was diagnosed with TS during his first hospitalization due to lower extremity deep venous thrombosis, pulmonary embolism, and thrombosis of the inferior vena cava, cerebral, left internal jugular, portal, renal, and iliac veins. He was eventually prescribed with rivaroxaban to control thrombosis after 30\u2009days of successive use of low-molecular-weight heparin, unfractionated heparin, and warfarin, which were demonstrating little effect on preventing thrombosis, and the patient was intolerant to argatroban. While his lupus anticoagulant ratio was slightly above the normal range and no other potential causes such as congenital thrombophilia, severe infection, malignancy, and trauma were confirmed, we suspected antiphospholipid antibody syndrome and prescribed glucocorticoid and rituximab to control the disease. After 36\u2009days of admission, ultrasonography showed recanalization of the former thrombus. One month after discharge, a tumor embolus resembling a mass emerged in his right atrium under effective anticoagulant therapy. During his second admission, he underwent surgical thrombectomy, and pathological examination confirmed the mass to be a platelet-rich thrombus rather than tumor embolus or infection. Considering the suspected antiphospholipid antibody syndrome as the cause of the TS, we prescribed aspirin combined with rivaroxaban to prevent thrombosis. In this case, surgery and pathology shed light on the type of thrombus that emerged from the inferior vena cava and traveled to the heart, which is the possible potential cause of TS. It also changed our therapeutic strategy to antiplatelet therapy combined with anticoagulant therapy to control the disease.<\/jats:p>","DOI":"10.1177\/2058738418778121","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T05:49:27Z","timestamp":1527227367000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Thrombotic storm in a 4-year-old boy with a thrombus in the right atrium"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-0876","authenticated-orcid":false,"given":"Jing-Yao","family":"Ma","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yun","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"bibr1-2058738418778121","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.10.018"},{"key":"bibr2-2058738418778121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.042"},{"key":"bibr3-2058738418778121","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2365"},{"key":"bibr4-2058738418778121","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00061-8"},{"key":"bibr5-2058738418778121","first-page":"541","volume":"15","author":"Miret C","year":"1997","journal-title":"Clinical and Experimental Rheumatology"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738418778121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2058738418778121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738418778121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:04:56Z","timestamp":1777457096000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2058738418778121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":5,"alternative-id":["10.1177\/2058738418778121"],"URL":"https:\/\/doi.org\/10.1177\/2058738418778121","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2058738418778121"}}