{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:04:22Z","timestamp":1787753062176,"version":"build-2784847793"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Centre of Postgraduate Medical Education","award":["501-1-21-27-17"],"award-info":[{"award-number":["501-1-21-27-17"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>Uterine fibroids (UFs) are one of the most common pathologies of the female genital tract. The incidence of UFs has been estimated at 25\u201380%. Tumor necrosis factor (TNF)-\u03b1 is a cell-signaling protein involved in systemic inflammation and is one of the cytokines responsible for the acute phase reaction. The aim of the study was to evaluate the impact of clinically symptomatic UFs on TNF-\u03b1 serum levels. A total of 149 Caucasian women were included: 85 patients admitted for surgery due to clinically symptomatic UFs (n\u2009=\u200985; study group) and 64 age-matched UF-free controls (n\u2009=\u200964). TNF-\u03b1 serum concentrations between the groups were compared. Receiver operating characteristic (ROC) curves were also used as a statistical model to evaluate TNF-\u03b1 as a marker for UFs. Mean TNF-\u03b1 serum concentration in the study group was 0.34\u2009\u00b1\u20090.14\u2009pg\/mL; (in half of the subjects, the level did not exceed 0.39\u2009pg\/mL. Mean TNF-\u03b1 serum concentration in the control group was 0.17\u2009\u00b1\u20090.09\u2009pg\/mL; in half of the subjects, the level did not exceed 0.14\u2009pg\/mL. The difference was statistically significant. Using the area under the ROC curve, we found that TNF-\u03b1 serum concentration of 0.34\u2009pg\/mL can be used as a predictor for UFs in selected populations. In our study, we confirmed higher TNF-\u03b1 serum concentrations in women with clinically symptomatic UFs.<\/jats:p>","DOI":"10.1177\/2058738418779461","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T10:27:15Z","timestamp":1527589635000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["TNF-\u03b1 serum levels are elevated in women with clinically symptomatic                     uterine fibroids"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Micha\u0142","family":"Ciebiera","sequence":"first","affiliation":[{"name":"First Department of Obstetrics and\r                Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"W\u0142odarczyk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and\r                Pharmacogenomics, Faculty of Pharmacy with the Laboratory Medicine Division, Medical\r                University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wrzosek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and\r                Pharmacogenomics, Faculty of Pharmacy with the Laboratory Medicine Division, Medical\r                University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Wojty\u0142a","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and\r                Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u0142a\u017cej","family":"M\u0119czekalski","sequence":"additional","affiliation":[{"name":"Department of Gynecological\r                Endocrinology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Nowicka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and\r                Pharmacogenomics, Faculty of Pharmacy with the Laboratory Medicine Division, Medical\r                University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"\u0141ukaszuk","sequence":"additional","affiliation":[{"name":"Department of Obstetric and\r                Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gda\u0144sk,\r                Gda\u0144sk, Poland"},{"name":"INVICTA Fertility and Reproductive\r                Center, Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Jakiel","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and\r                Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"bibr1-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.43"},{"key":"bibr2-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.007"},{"key":"bibr3-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr031"},{"key":"bibr4-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.007"},{"key":"bibr5-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2324-3"},{"key":"bibr6-2058738418779461","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00237-9"},{"issue":"5","key":"bibr7-2058738418779461","first-page":"2275","volume":"86","author":"Kurachi O","year":"2001","journal-title":"Journal of Clinical Endocrinology & 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