{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:43Z","timestamp":1777712383503,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key Project of Shandong Province","award":["NO. 2017GSF218106"],"award-info":[{"award-number":["NO. 2017GSF218106"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO. 81473188"],"award-info":[{"award-number":["NO. 81473188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81503059"],"award-info":[{"award-number":["No. 81503059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Poor prognosis is associated with melanoma due to immunosuppression profiles, suggesting that immune alterations have an important role in the occurrence, growth, and metastasis of melanoma. Here, we found that PCC0208018, a small-molecule compound, enhanced T cell proliferation and activation to release interferon gamma (IFN-\u03b3) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)\/programmed cell death-ligand 1 (PD-L1) binding and did not directly affect tumor cell viability in vitro. Furthermore, PCC0208018 increased the phosphorylation of protein kinase B (PKB\/AKT) as well as extracellular regulated protein kinases (ERK) in human peripheral blood mononuclear cells (PBMCs) in vitro. The secretion of cytokines induced by PCC0208018 was significantly suppressed by the PI3K inhibitor GDC-0941. In B16-F10 melanoma-harboring mice, PCC0208018 significantly inhibited tumor growth as well as increasing CD3\n                    <jats:sup>+<\/jats:sup>\n                    , CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    , and CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell abundance in tumors without affecting PD-L1 expression. This study showed that PCC0208018 potentially increased PBMCs proliferation and function by activating the phosphatidylinositol 3 kinase (PI3K)\/AKT and mitogen-activated protein kinase (MEK)\/ERK pathways to exert antitumor effects.\n                  <\/jats:p>","DOI":"10.1177\/2058738419843366","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T06:28:24Z","timestamp":1554877704000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["PCC0208018 exerts antitumor effects by activating effector T cells"],"prefix":"10.1177","volume":"33","author":[{"given":"Minmin","family":"Ge","sequence":"first","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengping","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Institute of Toxicology, Binzhou Medical University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-0544","authenticated-orcid":false,"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangying","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Institute of Toxicology, Binzhou Medical University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-0903","authenticated-orcid":false,"given":"Jingwei","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"bibr1-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1159\/000161125"},{"key":"bibr2-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.04.011"},{"key":"bibr3-2058738419843366","unstructured":"Sasikumar PGN, Ramachandra M, Naremaddepalli SSS (2015) 1,2,4-oxadiazole derivatives as immunomodulators. Available at: https:\/\/patents.google.com\/patent\/WO2015033299A1\/en?oq=WO2015033299."},{"key":"bibr4-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.01.015"},{"key":"bibr5-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.06.005"},{"key":"bibr6-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030589"},{"key":"bibr7-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14506"},{"key":"bibr8-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00857"},{"key":"bibr9-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1177\/2058738418787991"},{"key":"bibr10-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.22"},{"key":"bibr11-2058738419843366","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.11.7617"},{"key":"bibr12-2058738419843366","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.066"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419843366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2058738419843366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419843366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:13Z","timestamp":1777457113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2058738419843366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":12,"alternative-id":["10.1177\/2058738419843366"],"URL":"https:\/\/doi.org\/10.1177\/2058738419843366","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2058738419843366"}}