{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:36Z","timestamp":1787019396240,"version":"build-2736575974"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Alemtuzumab, an anti-CD52 monoclonal antibody, is effective in the treatment of relapsing\u2013remitting multiple sclerosis (RRMS). Common adverse effects include the development of autoimmune diseases, and Graves\u2019 disease is one of the most frequent presentations. We report here a case of alemtuzumab-induced thyroid disease in a female patient who showed a phase of thyrotoxicosis with positive anti-thyroglobulin (anti-Tg) and anti\u2013thyroid peroxidase (TPO) antibodies, but a negative TSH receptor antibody, spontaneously followed by hypothyroidism. The aim is to illustrate the clinical presentation, evaluation over time, and the possibility to consider a conservative management up to the spontaneous resolution of the thyrotoxicosis. All these are intended to emphasize the importance of pretreatment screening and follow-up in the management of treatment with alemtuzumab.<\/jats:p>","DOI":"10.1177\/2058738419843690","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T06:11:46Z","timestamp":1554876706000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Autoimmune thyroid disease following treatment with alemtuzumab for multiple sclerosis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-880X","authenticated-orcid":false,"given":"Angela","family":"Alamo","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Policlinico \u2018G. Rodolico\u2019, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita A","family":"Condorelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Policlinico \u2018G. Rodolico\u2019, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"La Vignera","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Policlinico \u2018G. Rodolico\u2019, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo E","family":"Calogero","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Policlinico \u2018G. Rodolico\u2019, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"bibr1-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1159\/000339757"},{"key":"bibr2-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"bibr3-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61769-3"},{"key":"bibr4-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00359"},{"key":"bibr5-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2201"},{"key":"bibr6-2058738419843690","first-page":"148","volume":"14","author":"Tsourdi E","year":"2015","journal-title":"Hormones"},{"key":"bibr7-2058738419843690","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00254"},{"key":"bibr8-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0934-5"},{"key":"bibr9-2058738419843690","doi-asserted-by":"publisher","DOI":"10.4158\/EP13020.RA"},{"key":"bibr10-2058738419843690","first-page":"2052","volume":"119","author":"Jones JL","year":"2009","journal-title":"Journal of Clinical Investigation"},{"key":"bibr11-2058738419843690","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-4-735"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419843690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2058738419843690","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419843690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:14Z","timestamp":1777457114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2058738419843690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":11,"alternative-id":["10.1177\/2058738419843690"],"URL":"https:\/\/doi.org\/10.1177\/2058738419843690","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2058738419843690"}}