{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:33:37Z","timestamp":1779935617043,"version":"3.53.1"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["31560051"],"award-info":[{"award-number":["31560051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81860644"],"award-info":[{"award-number":["81860644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81560596"],"award-info":[{"award-number":["81560596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"natural science foundation of yunnan province","doi-asserted-by":"publisher","award":["2014FA011"],"award-info":[{"award-number":["2014FA011"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"natural science foundation of yunnan province","doi-asserted-by":"publisher","award":["2017FE467-001"],"award-info":[{"award-number":["2017FE467-001"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Cytokines play a crucial role in mediating immune responses to tuberculosis (TB). The aim of this study was to evaluate the levels of cytokines in patients with different forms of pulmonary tuberculosis (PTB) and identify valuable cytokine biomarkers for the diagnosis of PTB. We measured the levels of six cytokines (interleukin (IL-2, IL-4, IL-6, and IL-10), tumor necrosis factor (TNF-\u03b1), and interferon-\u03b3 (IFN-\u03b3)) in the serum of healthy donors (n\u2009=\u200930). Patients with active PTB (n\u2009=\u200946) and those with latent tuberculosis infection (LTBI, n\u2009=\u200938) were examined using cytometric bead arrays. The levels of the six cytokines in the serum samples were measured promptly, sensitively, and simultaneously. The levels of IL-2, IL-6, IL-10, and IFN-\u03b3 were significantly higher in the PTB group compared with those reported in the healthy donors ( P\u2009&lt;\u20090.01 or P\u2009&lt;\u20090.05). In addition, significantly higher levels of IL-2, IL-6, IL-10, and IFN-\u03b3 were found in the active PTB group compared with those observed in the LTBI group ( P\u2009&lt;\u20090.01 or P\u2009&lt;\u20090.05). However, the levels of IL-4 and TNF-\u03b1 in the sera of patients from the PTB group did not show a significant correlation with those measured in the healthy donor group. Our data demonstrated that IL-2, IL-6, IL-10, and IFN-\u03b3 may be useful in the auxiliary diagnosis of tuberculosis and as biomarkers for distinguishing LTBI from TB.<\/jats:p>","DOI":"10.1177\/2058738419845176","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T06:01:37Z","timestamp":1555999297000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Using cytometric bead arrays to detect cytokines in the serum of patients with different types of pulmonary tuberculosis"],"prefix":"10.1177","volume":"33","author":[{"given":"Ruolan","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kunming Medical University, Kunming, China"},{"name":"Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"},{"name":"Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming, China"},{"name":"The Institute for Tropical Medicine, Kunming Medical University, Kunming, China"},{"name":"Yunnan Province Integrative Innovation Center for Public Health, Diseases Prevention and Control, Kunming Medical University, Kunming, China"},{"name":"Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiting","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taigui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-6660","authenticated-orcid":false,"given":"Fukai","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kunming Medical University, Kunming, China"},{"name":"Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming, China"},{"name":"The Institute for Tropical Medicine, Kunming Medical University, Kunming, China"},{"name":"Yunnan Province Integrative Innovation Center for Public Health, Diseases Prevention and Control, Kunming Medical University, Kunming, China"},{"name":"Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"bibr1-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.04.009"},{"key":"bibr2-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TNMI7-0032-2016"},{"key":"bibr3-2058738419845176","volume-title":"Global Tuberculosis Report 2016","author":"World Health Organization","year":"2016"},{"key":"bibr4-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00620-13"},{"key":"bibr5-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2190-z"},{"key":"bibr6-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03104.x"},{"key":"bibr7-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079742"},{"key":"bibr8-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.7"},{"key":"bibr9-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.09.001"},{"key":"bibr10-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.06.002"},{"key":"bibr11-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02976.x"},{"key":"bibr12-2058738419845176","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2018.5"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419845176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2058738419845176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738419845176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:14Z","timestamp":1777457114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2058738419845176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":12,"alternative-id":["10.1177\/2058738419845176"],"URL":"https:\/\/doi.org\/10.1177\/2058738419845176","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2058738419845176"}}