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However, phenotype concordance for orofacial cleft in monozygotic twins is about 50%. The aim of the present investigation was to detect postzygotic events that may account for discordance in monozygotic twins. High-density SNP microarrays hybridization was used to genotype two pairs of monozygotic twins discordant for nsCL\/P. Discordant SNP genotypes and copy number variants were analyzed to identify genetic differences responsible of phenotype discrepancy. A number of differences were observed, none involving known nsCL\/P candidate genes or genomic regions. Considering the limitation of the study, related to the small sample size and to the large-scale investigation method, the results suggest that the detection of discordant events in other monozygotic twin pairs would be remarkable and warrant further investigations.<\/jats:p>","DOI":"10.1177\/2058738419855873","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T07:23:01Z","timestamp":1572420181000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Copy number variation analysis of twin pairs discordant for cleft lip with or without cleft palate"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-9910","authenticated-orcid":false,"given":"Luca","family":"Scapoli","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, 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