{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:12:43Z","timestamp":1789186363677,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shandong Pharmaceutical Association Clinical Pharmacy Asei Kang Young and Middle-aged Research Funding Project","award":["Sdpa-ask -2011-01"],"award-info":[{"award-number":["Sdpa-ask -2011-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    The infection of the bone marrow system caused by methicillin-resistant Staphylococcus aureus (MRSA) leads to a variety of common diseases which usually occur in children under the age of 12. Vancomycin (VCM) is the first-line therapy for MRSA-caused serious infections such as bacteremia, infective endocarditis, osteomyelitis, meningitis, pneumonia, and severe skin and soft-tissue infection (e.g. necrotizing fasciitis) with a recommended dosage of 15\u201320\u2009\u03bcg\/mL. In this study, we first report a case of a child with MRSA-caused osteomyelitis who was successfully cured by VCM at a concentration of 4.86\u2009\u03bcg\/mL. VCM\u2019s clinical daily dose of more than 4\u2009g was of concern in light of recent evidence suggesting the increased risks of nephrotoxicity and red man syndrome when C\n                    <jats:sub>min<\/jats:sub>\n                    \u2a7e15\u2009\u03bcg\/mL and doses \u2a7e10\u2009mg\/kg in children. As far as we know, this is the first report on the lower dose of VCM in children with MRSA osteomyelitis.\n                  <\/jats:p>","DOI":"10.1177\/2058738420925713","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T06:01:40Z","timestamp":1592719300000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pediatric pharmaceutical care with anti-infective medication in a patient with acute hematogenous osteomyelitis caused by methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1177","volume":"34","author":[{"given":"Chanmei","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The People\u2019s Hospital Of Huaiyin, Jinan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Dongying Shengli Shengcai Hospital, Dongying, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-2019","authenticated-orcid":false,"given":"Dongna","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"bibr1-2058738420925713","first-page":"2080","volume":"14","author":"Yang BG","year":"2012","journal-title":"China Health Industry"},{"key":"bibr2-2058738420925713","first-page":"54","volume":"24","author":"Qin YR","year":"2018","journal-title":"Journal of Pediatric Pharmacy"},{"key":"bibr3-2058738420925713","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"bibr4-2058738420925713","first-page":"641","volume":"30","author":"Vancomycin Clinical Application Dose Expert Group","year":"2012","journal-title":"Chinese Journal of Infectious Diseases"},{"key":"bibr5-2058738420925713","first-page":"74","volume":"21","author":"Meng L","year":"2013","journal-title":"Pharmaceutical and Clinical Research"},{"key":"bibr6-2058738420925713","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318286378e"},{"key":"bibr7-2058738420925713","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1007320"},{"key":"bibr8-2058738420925713","first-page":"261","volume":"7","author":"Vitrat V","year":"2014","journal-title":"Infection and Drug Resistance"},{"issue":"12","key":"bibr9-2058738420925713","first-page":"630","volume":"122","author":"Matuszkiewicz-Rowinska J","year":"2012","journal-title":"Polskie Archiwum Medycyny Wewnetrznej"},{"key":"bibr10-2058738420925713","first-page":"217","volume":"23","author":"Wang CJ","year":"2008","journal-title":"Foreign Medical Sciences"},{"key":"bibr11-2058738420925713","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000346"},{"key":"bibr12-2058738420925713","first-page":"561","volume":"30","author":"Chen YY","year":"2011","journal-title":"Chinese Journal of New Drugs and Clinical Medicine"},{"key":"bibr13-2058738420925713","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181906e40"},{"key":"bibr14-2058738420925713","first-page":"1393","volume":"26","author":"Gao P","year":"2016","journal-title":"Chinese Journal of Nosocomiology"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738420925713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2058738420925713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2058738420925713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:22Z","timestamp":1777457122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2058738420925713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":14,"alternative-id":["10.1177\/2058738420925713"],"URL":"https:\/\/doi.org\/10.1177\/2058738420925713","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2058738420925713"}}