{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:00:48Z","timestamp":1777712448695,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"beijing municipal science and technology commission","doi-asserted-by":"publisher","award":["Z181100001718182"],"award-info":[{"award-number":["Z181100001718182"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capitals Funds for Health Improvement and Research of China","award":["CFH 2018-2-2094"],"award-info":[{"award-number":["CFH 2018-2-2094"]}]},{"name":"National Science and Technology Key Projects","award":["2017ZX09304029004"],"award-info":[{"award-number":["2017ZX09304029004"]}]},{"name":"Beijing Natural Science Foundation of China","award":["7162059"],"award-info":[{"award-number":["7162059"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The factor VIII (FVIII)-neutralizing antibody (inhibitor) seen in 25%\u201330% of patients with severe haemophilia A (SHA). Vaccination is a non-genetic risk factor of inhibitor development as \u2018danger signal\u2019 which may provide a pro-inflammatory microenvironment to increase FVIII immunogenicity. We reported a previously treated SHA patient postponed the first vaccination to 15-month age received diphtheria-pertussis-tetanus intramuscularly. At 18-month age, the patient received Hepatitis A intramuscularly and Varicella Zoster Virus subcutaneously with 2\u2009weeks interval and FVIII infusion was given &lt;24\u2009h prior for each. Successive bleedings occurred 1\u2009week later with inefficacy of FVIII replacement. High-titre inhibitor was tested at 117 exposure days. This case suggested that continuous vaccinations in close proximity to FVIII could induce inhibitor. The relationship between vaccination and FVIII immunogenicity still needs to be revealed by further study.<\/jats:p>","DOI":"10.1177\/2058738420934618","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T07:35:48Z","timestamp":1594020948000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A previously treated severe haemophilia A patient developed high-titre inhibitor after vaccinations"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1421-4590","authenticated-orcid":false,"given":"Zekun","family":"Li","sequence":"first","affiliation":[{"name":"Hemophilia Work Group, Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[{"name":"Hemophilia Work Group, Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-2658","authenticated-orcid":false,"given":"Xiaoling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hemophilia Work Group, Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Hemophilia Work Group, Hematology Oncology Center, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, 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