{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:40:03Z","timestamp":1790750403333,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK\u2009+\u2009ALCL) is most frequent in youth and possesses a broad morphologic spectrum. However, involvement in central nervous system (CNS) is definitely rare. The case we presented was a 12-year-old Chinese male who presented with headache and emesis for a couple of days. The neoplastic component was smaller cells resembling starry-sky growth pattern and immunohistochemical stained positively for CD30, ALK1, and CD56. Monoclonal T-cell receptor (TCR\u03b3) gene rearrangement and gene translocation involving ALK identified by fluorescence in situ hybridization (FISH) using ALK break apart probe supported the diagnosis of ALK\u2009+\u2009ALCL. This case showed ALK\u2009+\u2009ALCL occur in a rare site with an abnormal CD56 expression. Awareness of this entity is important to distinguish it from other intracranial lymphoma.<\/jats:p>","DOI":"10.1177\/2058738420941756","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T04:31:27Z","timestamp":1594787487000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: Challenge in diagnostic practice"],"prefix":"10.1177","volume":"34","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, Jiangxi Provincial People\u2019s Hospital Affiliated to Nanchang University, Nanchang, China"},{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gandi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-2763","authenticated-orcid":false,"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"bibr1-2058738420941756","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. 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