{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:54Z","timestamp":1792007694859,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Youth Talent Training Plan of Shanghai Municipal Hospital of Traditional Chinese Medicine","award":["2019PY003"],"award-info":[{"award-number":["2019PY003"]}]},{"DOI":"10.13039\/100000026","name":"natural science foundation of shanghai","doi-asserted-by":"publisher","award":["09ZR1429700"],"award-info":[{"award-number":["09ZR1429700"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"the Budgetary Foundation of Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["18LK074"],"award-info":[{"award-number":["18LK074"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["19YF1445200"],"award-info":[{"award-number":["19YF1445200"]}]},{"name":"Outstanding Academic Leader of Health System of Shanghai","award":["XBR2013120"],"award-info":[{"award-number":["XBR2013120"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573775,881873157"],"award-info":[{"award-number":["81573775,881873157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    NLRP3 inflammasome activation results in severe liver inflammation and injury. Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study aimed to determine the protective effects of SSd on carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )-induced acute liver injury in mice, and whether oxidative stress and NLRP3 inflammasome activation participate in the process.\n                  <\/jats:p>\n                  <jats:p>\n                    The CCl\n                    <jats:sub>4<\/jats:sub>\n                    mice model and controls were induced. The mice were treated with SSd at 1, 1.5, or 2.0\u2009mg\/kg in a total volume of 100\u2009\u00b5l\/25\u2009g of body weight. Liver injury was assessed by histopathology. Oxidative stress was determined using mitochondrial superoxide production (MSP), malondialdehyde (MDA) content, and superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities. NLRP3, ASC, and Caspase 1 were determined by real-time PCR and western blot. IL-1\u03b2 and IL-18 levels were determined by ELISA.\n                  <\/jats:p>\n                  <jats:p>\n                    Significantly elevated oxidative stress was induced in the liver by CCl\n                    <jats:sub>4<\/jats:sub>\n                    , as demonstrated by histopathology and increases of MDA and MSP levels and decreases of SOD, GPx, and CAT activities (all P\u2009&lt;\u20090.01). SSd significantly decreased the MDA and MSP levels and increased the activities of SOD, GPx, and CAT (all P\u2009&lt;\u20090.05). The mRNA expression of NLRP3, ASC, and Caspase 1, and the protein expression of Caspase 1-p10, NLRP3, ASC, IL-1\u03b2, and IL-18 were significantly increased after CCl\n                    <jats:sub>4<\/jats:sub>\n                    induction (all P\u2009&lt;\u20090.01). These changes were reversed by SSd (all P\u2009&lt;\u20090.05).\n                  <\/jats:p>\n                  <jats:p>\n                    Suppression of the oxidative stress and NLRP3 inflammasome activation were involved in SSd-alleviated acute liver injury in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hepatitis.\n                  <\/jats:p>","DOI":"10.1177\/2058738420950593","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T14:08:23Z","timestamp":1597932503000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice"],"prefix":"10.1177","volume":"34","author":[{"given":"Yirong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renye","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai TCM Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-4871","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"bibr1-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301733"},{"key":"bibr2-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.015"},{"key":"bibr3-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26592"},{"key":"bibr4-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60777"},{"key":"bibr5-2058738420950593","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17078334"},{"key":"bibr6-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu114"},{"key":"bibr7-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1139\/O07-010"},{"key":"bibr8-2058738420950593","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.891355"},{"key":"bibr9-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.02.024"},{"key":"bibr10-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.11.006"},{"key":"bibr11-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.08.014"},{"key":"bibr12-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13123"},{"key":"bibr13-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.08.006"},{"key":"bibr14-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.11.005"},{"key":"bibr15-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1400104"},{"key":"bibr16-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph1430s66"},{"key":"bibr17-2058738420950593","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.035"},{"key":"bibr18-2058738420950593","first-page":"330","volume":"15","author":"Zelen 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