{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:02:03Z","timestamp":1777712523218,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Minimization in immunosuppression could contribute to the appearance the donor-specific HLA antibodies (DSA) and graft failure. The objective was to compare the incidence of DSA in renal transplantation (RT) in recipients with immunosuppression with and without steroids. A prospective cohort from March 1st, 2013 to March 1st, 2014 and follow-up (1\u2009year), ended in March 2015, was performed in living donor renal transplant (LDRT) recipients with immunosuppression and early steroid withdrawal (ESW) and compared with a control cohort (CC) of patients with steroid-sustained immunosuppression. All patients were negative cross-matched and for DSA pre-transplant. The regression model was used to associate the development of DSA antibodies and acute rejection (AR) in subjects with immunosuppressive regimens with and without steroids. Seventy-seven patients were included (30 ESW and 47 CC). The positivity of DSA class I (13% vs 2%; P\u2009&lt;\u20090.05) and class II (17% vs 4%, P\u2009=\u20090.06) antibodies were higher in ESW versus CC. The ESW tended to predict DSA class II (RR 5.7; CI (0.93\u201334.5, P\u2009=\u20090.06). T-cell mediated rejection presented in 80% of patients with DSA class I ( P\u2009=\u20090.07), and 86% with DSA II ( P\u2009=\u20090.03), and was associated with DSA class II, (RR 7.23; CI (1.2\u201344), P\u2009=\u20090.03). ESW could favor the positivity of DSA. A most strictly monitoring the DSA is necessary for the early stages of the transplant to clarify the relationship between T-cell mediated rejection and DSA.<\/jats:p>","DOI":"10.1177\/20587384211000545","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T02:22:51Z","timestamp":1617330171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Donor-specific antibodies development in renal living-donor receptors: Effect of a single cohort"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-8223","authenticated-orcid":false,"given":"Jorge","family":"Andrade-Sierra","sequence":"first","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"},{"name":"Department of Physiology, University Health 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M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 I","family":"Cerrillos-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Gonz\u00e1lez-Espinoza","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A","family":"Evangelista-Carrillo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Medina-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilio","family":"Jalomo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Nieves Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Pazar\u00edn-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia A","family":"Mendoza-Cerpa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"G\u00f3mez-Navarro","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-6135","authenticated-orcid":false,"given":"Alejandra G","family":"Miranda-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, 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