{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:22Z","timestamp":1793381062866,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"national key research and development program of china","doi-asserted-by":"publisher","award":["No. 2016YFC0901500"],"award-info":[{"award-number":["No. 2016YFC0901500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81671614"],"award-info":[{"award-number":["81671614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Science","award":["2017-I2M-3-001"],"award-info":[{"award-number":["2017-I2M-3-001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The relapsing polychondritis (RP) patients with central nervous system (CNS) involvement were rare. We aimed to determine the clinical characteristics of RP patients with CNS involvement. The clinical data of 181 RP patients, hospitalized at Peking Union Medical College Hospital between December 2005 and February 2019, were collected. The patients were categorized into two subgroups: 25 RP patients with CNS involvement, and 156 RP patients without CNS involvement. The involvement of the ear was more frequent in RP patients with CNS involvement, compared with those of RP patients without CNS involvement ( P\u2009&lt;\u20090.01). After controlling sex and the admission age, logistic regression analysis revealed hypertension (odds ratio\u2009=\u20094.308, P\u2009=\u20090.006) and involvement of eye (odds ratio\u2009=\u20095.158, P\u2009=\u20090.001) and heart (odds ratio\u2009=\u20093.216, P\u2009=\u20090.025) were correlated with RP patients with CNS involvement, respectively. In addition, pulmonary infection (odds ratio\u2009=\u20090.170, P\u2009=\u20090.020), tracheal involvement (odds ratio\u2009=\u20090.073, P\u2009&lt;\u20090.01), and involvement of laryngeal (odds ratio\u2009=\u20090.034, P\u2009=\u20090.001), costochondral joint (odds ratio\u2009=\u20090.311, P\u2009=\u20090.013), sternoclavicular joint (odds ratio\u2009=\u20090.163, P\u2009=\u20090.017) and manubriosternal joint (odds ratio\u2009=\u20090.171, P\u2009=\u20090.021) were associated with RP patients without CNS involvement, respectively. In contrast to RP patients without CNS involvement, the incidence of ear involvement was higher in RP patients with CNS involvement. After controlling the potential confounding factor sex and the admission age, hypertension and involvement of eye and heart were related with RP patients with CNS involvement, respectively.<\/jats:p>","DOI":"10.1177\/20587384211000547","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T23:17:06Z","timestamp":1616455026000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of relapsing polychondritis patients with and without central nervous system involvement: A retrospective study of 181 patients"],"prefix":"10.1177","volume":"35","author":[{"given":"Xiaoyu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"},{"name":"Department of Rheumatology and Clinical Immunology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ningde Hospital Affiliated to Fujian Medical University, Ningde, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Handan First Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-6965","authenticated-orcid":false,"given":"Yong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"bibr1-20587384211000547","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex406"},{"key":"bibr2-20587384211000547","first-page":"2181","volume":"54","author":"Hazra N","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"bibr3-20587384211000547","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23492"},{"key":"bibr4-20587384211000547","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91439"},{"key":"bibr5-20587384211000547","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1059-7"},{"key":"bibr6-20587384211000547","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3616-7"},{"key":"bibr7-20587384211000547","first-page":"43","volume":"99","author":"Tsai 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