{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:37:54Z","timestamp":1777711074768,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Objective: Being overweight is associated with an increased risk of diabetes mellitus, hypertension, and cardiovascular disease. Lipoprotein-associated phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    (Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    ) can independently predict the risk of cardiovascular disease. This study is aimed to investigate whether Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    was associated with an overweight status. Methods: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18\u201350\u00a0years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    , after correcting for possible influencing factors. Results: The Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    level was greater in male than in female subjects ( p &lt; 0.001). Subjects with a central overweight status had a greater Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    level than those with normal weight and a peripheral overweight status, in both male and female cohorts. The Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    level was significantly greater in those with additional comorbidities (namely diabetes mellitus (DM), hypertension (HTN), overweight, and metabolic syndrome (MetS)). The age-adjusted and LDL-adjusted Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    level also was significantly higher in the DM (+) and HTN (\u2212) subgroups than in the DM (\u2212), HTN (\u2212), DM (\u2212), and HTN (+) subgroups. Conclusion: Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    is associated with sex, central overweight status, diabetes, hypertension, and MetS in adults aged &lt; 50\u00a0years and the age-adjusted and LDL-adjusted Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    was significantly higher in the DM (+) and HTN (\u2212) subgroups than in the DM (\u2212) and HTN (\u2212) and DM (\u2212) and HTN (+) subgroups.\n                  <\/jats:p>","DOI":"10.1177\/20587384211048562","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T06:29:24Z","timestamp":1637303364000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The correlation between lipoprotein associated phospholipase A\n                    <sub>2<\/sub>\n                    and central overweight status"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-4455","authenticated-orcid":false,"given":"Yi-Hsuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Department of Health Management, Xiamen Chang-Gung Hospital, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chung","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Health Management, Xiamen Chang-Gung Hospital, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiung Ying","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xiamen Chang-Gung Hospital, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong-Xue","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiamen Chang-Gung Hospital, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-7833","authenticated-orcid":false,"given":"Jau-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"bibr1-20587384211048562","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/289645"},{"key":"bibr2-20587384211048562","first-page":"174","volume":"71","author":"Van Greevenbroek MM","year":"2013","journal-title":"The Netherlands Journal of 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