{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:39:53Z","timestamp":1777711193917,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cFAEPEX\u201d - Fund for Support to Teaching, Research and Outreach Activities - from University of Campinas","award":["519.292"],"award-info":[{"award-number":["519.292"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Objectives: Plasmacytoid dendritic cells (pDCs) have been shown to have a role in autoimmune diseases, but their role in Autoimmune Hepatitis (AIH) is not completely clear. In the present study, we assessed the frequency of pDCs in peripheral blood of AIH patients under long-term standard immunosuppressive therapy. Methods: This cross-sectional analysis enrolled 27 AIH patients and 27 healthy controls. We analyzed and compared their proportion of pDCs, CD4\n                    <jats:sup>+<\/jats:sup>\n                    , CD8\n                    <jats:sup>+<\/jats:sup>\n                    , \u03b3\u03b4 T cells, CD25\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T (Treg) cells, FoxP3\n                    <jats:sup>+<\/jats:sup>\n                    , Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    CD39\n                    <jats:sup>+<\/jats:sup>\n                    Treg cells, total B (CD19\n                    <jats:sup>+<\/jats:sup>\n                    ) cells, and plasma cells (CD38\n                    <jats:sup>+<\/jats:sup>\n                    ) in peripheral blood using flow cytometry immunophenotyping. Results: AIH patients had a lower percentage of pDCs (median frequencies of 0.2% vs. 0.4%; p = .002) and higher expression of CD8 T cells (32.5% vs 28.6%; p = 0.008) in peripheral blood, when compared to healthy controls. We did not find statistically significant differences between the groups regarding the other cell subtypes.Conclusion: Our data suggest a persistent suppression of pDCs in AIH patients, along with increased CD8 T cell activity, years after AIH diagnosis and despite of good clinical response to treatment, thus pointing to a role of pDCs in the AIH pathogenesis.\n                  <\/jats:p>","DOI":"10.1177\/20587384211068667","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:08:43Z","timestamp":1649678923000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Patients with treated autoimmune hepatitis and persistent suppression of plasmacytoid dendritic cells: A different point of view"],"prefix":"10.1177","volume":"36","author":[{"given":"Irene P","family":"dos Santos","sequence":"first","affiliation":[{"name":"Center for Hematology and Hemotherapy, University of Campinas, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra T","family":"de Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Clinic, Hospital de Cl\u00ednicas (University of Campinas Teaching Hospital), University of Campinas, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-0156","authenticated-orcid":false,"given":"Renan M","family":"Mauch","sequence":"additional","affiliation":[{"name":"Center for Investigation in Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-8984","authenticated-orcid":false,"given":"Natascha Silva","family":"Sandy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Tadeu","family":"Nolasco da Silva","sequence":"additional","affiliation":[{"name":"Center for Investigation in Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil"},{"name":"Department of Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angela","family":"Bellomo-Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Clinic, Hospital de Cl\u00ednicas (University of Campinas Teaching Hospital), University of Campinas, Campinas, Brazil"},{"name":"Department of Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-3591","authenticated-orcid":false,"given":"Adriana Gut 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