{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:43Z","timestamp":1753882903464,"version":"3.41.2"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scars, Burns &amp; Healing"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Backgrounds\/objectives:<\/jats:title><jats:p> Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> There was a statistically significant difference in survivin and IGF-I levels between controls and patients ( P &lt; 0.05). However, there was no linear correlation between survivin and IGF-I. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2059513118818031","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T12:09:19Z","timestamp":1547122159000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar"],"prefix":"10.1177","volume":"5","author":[{"given":"Samar","family":"El-Tahlawi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Ezzat Mohammad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza","family":"Mohamed El-Amir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Sayed Mohamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"bibr1-2059513118818031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.019"},{"key":"bibr2-2059513118818031","doi-asserted-by":"crossref","unstructured":"Alper M, Khurami FA. Histopathologic evaluation of acneiform eruptions: practical algorithmic proposal for acne lesions. In: Kartal SP, Gonul M (eds) Acne and Acneiform Eruptions. InTech 2017; 139\u2013160. 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