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The objective of this study was to evaluate whether baseline clinical variables, three-month RTW, and three-month postconcussional symptoms (PCS) were associated with six-month RTW after mTBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult subjects from the prospective multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot study with mTBI (Glasgow Coma Scale 13\u201315) who were employed at baseline, with completed three- and six-month RTW status, and three-month Acute Concussion Evaluation (ACE), were extracted. Univariate and multivariable analyses were performed for six-month RTW, with focus on baseline employment, three-month RTW, and three-month ACE domains (physical, cognitive, sleep, and\/or emotional postconcussional symptoms (PCS)). Odds ratios (OR) and 95% confidence intervals [CI] were reported. Significance was assessed at p\u2009&lt;\u20090.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 152 patients aged 40.7\u2009\u00b1\u200915.0\u2009years, 72% were employed full-time at baseline. Three- and six-month RTW were 77.6% and 78.9%, respectively. At three months, 59.2%, 47.4%, 46.1% and 31.6% scored positive for ACE physical, cognitive, sleep, and emotional PCS domains, respectively. Three-month RTW predicted six-month RTW (OR\u2009=\u200919.80, 95% CI [7.61\u201351.52]). On univariate analysis, scoring positive in any three-month ACE domain predicted inability for six-month RTW (OR\u2009=\u20090.10\u20130.11). On multivariable analysis, emotional symptoms predicted inability to six-month RTW (OR\u2009=\u20090.19 [0.04\u20130.85]). Subjects who scored positive in all four ACE domains were more likely to be unable to RTW at six months (4 domains: 58.3%, vs. 0-to-3 domains: 9.5%; multivariable OR\u2009=\u20090.09 [0.02\u20130.33]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three-month post-injury is an important time point at which RTW status and PCS should be assessed, as both are prognostic markers for six-month RTW. Clinicians should be particularly vigilant of patients who present with emotional symptoms, and patients with symptoms across multiple PCS categories, as these patients are at further risk of inability to RTW and may benefit from targeted evaluation and support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20597002211007271","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T13:13:05Z","timestamp":1617714785000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Predictors of six-month inability to return to work in previously employed subjects after mild traumatic brain injury: A TRACK-TBI pilot study"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-7722","authenticated-orcid":false,"given":"John K","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan RL","family":"Phelps","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-6107","authenticated-orcid":false,"given":"Debra D","family":"Hemmerle","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan S","family":"Upadhyayula","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan A","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J","family":"Vassar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina R","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Schnyer","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Texas, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester F","family":"Lingsma","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava M","family":"Puccio","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther L","family":"Yuh","sequence":"additional","affiliation":[{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"},{"name":"Department of Radiology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"},{"name":"Department of Radiology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B","family":"Ngwenya","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Cincinnati, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex B","family":"Valadka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy 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