{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:43:11Z","timestamp":1777858991131,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Prim Care Community Health"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is one of the most common types of cardiac amyloidosis. Amyloid cardiomyopathy more commonly affects men, elderly, and 3% to 4% of the African-American population. ATTR-CM suspicion and diagnosis is challenging; however, awareness of the disease is increasing, and best practices to identify it are being proposed. The approach to suspected cases of ATTR-CM relies on the presence of heart failure, red flag signs and symptoms, and age &gt;65 or &gt;70 for men and women respectively. Little is known about cases when it presents in early ages. Case: We report a 62-year-old African American male with past medical history of hyperlipidemia, prostate cancer, hypertension, bilateral carpal tunnel surgery that had debuted with a cardiac arrhythmia at age 55 and was diagnosed with heart failure several years later. Restrictive cardiomyopathy was suspected, and genetic screening was sent for ATTRm which confirmed a pathogenic trasnthyretin gene mutation. Endomyocardial biopsy was performed which confirmed cardiac amyloid deposition. Discussion: ATTR-CM is a rare disease with an increasing prevalence. Cases with out of proportion signs and symptoms of heart failure with preserved ejection fractions should raise the suspicion of ATTR-CM despite age.<\/jats:p>","DOI":"10.1177\/21501319211062682","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T01:47:25Z","timestamp":1641347245000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Early Hereditary Transthyretin Amyloid Cardiomyopathy Recognition With Genetic Screening: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"given":"Michel","family":"Juarez","sequence":"first","affiliation":[{"name":"Center for Research in Indigenous Health, Wuqu\u2019 Kawoq|Maya Health Alliance, Tecp\u00e1n, Chimaltenango, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-0730","authenticated-orcid":false,"given":"Gaspar","family":"Del Rio-Pertuz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanak","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie C.","family":"Bois","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Shurmur","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Argueta-Sosa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"bibr1-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.04.010"},{"key":"bibr2-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005407"},{"key":"bibr3-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.09.025"},{"key":"bibr4-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2093"},{"key":"bibr5-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.12241"},{"key":"bibr6-21501319211062682","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2011.574354059"},{"key":"bibr7-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1177\/11795468211015230"},{"key":"bibr8-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0726-x"},{"key":"bibr9-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006075"},{"key":"bibr10-21501319211062682","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa382"}],"container-title":["Journal of Primary Care &amp; Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319211062682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501319211062682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319211062682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:23:13Z","timestamp":1777508593000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501319211062682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"alternative-id":["10.1177\/21501319211062682"],"URL":"https:\/\/doi.org\/10.1177\/21501319211062682","relation":{},"ISSN":["2150-1319","2150-1327"],"issn-type":[{"value":"2150-1319","type":"print"},{"value":"2150-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"21501319211062682"}}