{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:44:31Z","timestamp":1777859071481,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"South Yorkshire, Bassetlaw & North Derbyshire Cancer Alliance"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Prim Care Community Health"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction\/Objectives:<\/jats:title>\n                    <jats:p>The fecal immunochemical test (FIT) helps triage primary care patients at risk of colorectal cancer (CRC). Improving FIT returns has received recent attention, however uncertainty exists regarding the accurate completion of samples provided for laboratory analysis. This study aims to identify the rejection rate of returned FIT samples and determine rejection causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>FIT samples from symptomatic patients within South Yorkshire, Bassetlaw, and North Derbyshire are processed at a central laboratory. Tests requests are made from 225 GP practices, which serve an estimated 2\u2009million population. This study describes a retrospective review of FIT samples received in the central laboratory between 01\/09\/19 and 31\/12\/22. Locally held data was interrogated in March 2023 to determine the number of FIT samples received and rejected during the study period. Documented reasons for rejection were explored to identify common themes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Total FIT specimens received during the study period was 126\u2009422. Of these, 5190 (4.1%) were rejected. Monthly rejection rates fell from 17.4% in September 2019 to 1.3% in December 2022 ( P\u2009&lt;\u2009.001). Sampling errors were the most frequent cause for FIT rejection (2151\/5190), with other causes including: expired specimen; no sample collection date\/ time, no request form, incomplete patient information and illegible handwriting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first study exploring FIT rejection rates in symptomatic primary care patients, which shows improvements in rejection rates over time. Targeted interventions could improve rejection rates further, thereby reducing NHS resource use and costs and diagnostic delays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501319241228161","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T03:51:59Z","timestamp":1707796319000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rejection of Fecal Immunochemical Tests Within the Lower Gastrointestinal Diagnostic Pathway: A Cohort Study"],"prefix":"10.1177","volume":"15","author":[{"given":"Alex J.","family":"Ball","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK"},{"name":"Division of Clinical Medicine, School of Medicine & Population Health, University of Sheffield, Sheffield, South Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravishankar B.","family":"Sargur","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Merriman","sequence":"additional","affiliation":[{"name":"Springs Health Centre, Chesterfield, Derbyshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-9500","authenticated-orcid":false,"given":"Matthew","family":"Kurien","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK"},{"name":"Division of Clinical Medicine, School of Medicine & Population Health, University of Sheffield, Sheffield, South Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"bibr1-21501319241228161","unstructured":"Cancer Research UK. Bowel Cancer Survival. 2018. Accessed June 7, 2023. https:\/\/www.cancerresearchuk.org\/about-cancer\/bowel-cancer\/survival#:~:text=Survival%20for%20all%20stages%20of%20bowel%20cancer&text=around%2075%20out%20of%20100"},{"key":"bibr2-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.48"},{"key":"bibr3-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.109"},{"key":"bibr4-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30392-2"},{"key":"bibr5-21501319241228161","unstructured":"National Institute for Health and Care Excellence. Quantitative faecal immunochemical tests to guide referral for colorectal cancer in primary care. DG30. NICE. 2017. Accessed July 7, 2023. https:\/\/www.nice.org.uk\/guidance\/dg30"},{"key":"bibr6-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221117636"},{"key":"bibr7-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2021-101825"},{"key":"bibr8-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30185-0"},{"key":"bibr9-21501319241228161","unstructured":"National Institute for Health and Care Excellence. Clinical guide for triaging patients with lower gastrointestinal symptoms; 2020. Accessed July 7, 2023. https:\/\/www.nice.org.uk\/media\/default\/about\/covid-19\/specialty-guides\/triaging-patients-with-lower-gi-symptoms.pdf"},{"key":"bibr10-21501319241228161","unstructured":"British Society of Gastroenterology. Joint ACPGBI, BSG and BSGAR considerations for adapting the rapid access colorectoral cancer pathway during COVID-19 pandemic. 2022. Accessed July 1, 2023. https:\/\/www.bsg.org.uk\/covid-19-advice\/covid-19-advice-for-healthcare-professionals\/joint-acgbbi-bsg-and-bsgar-considerations-for-adapting-the-rapid-access-colorectoral-cancer-pathway-during-covid-19-pandemic\/"},{"key":"bibr11-21501319241228161","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp.2023.0033"},{"key":"bibr12-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1007\/s13187-013-0551-4"},{"key":"bibr13-21501319241228161","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO.2021.0102"},{"key":"bibr14-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2364-3"},{"key":"bibr15-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1097\/JHQ.0000000000000181"},{"key":"bibr16-21501319241228161","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.7037"},{"key":"bibr17-21501319241228161","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2022.0241"},{"key":"bibr18-21501319241228161","unstructured":"Transformation Partners in Health and Care. Improving the quality of symptomatic FIT for bowel cancer. 2022. Accessed July 1, 2023. https:\/\/www.transformationpartnersinhealthandcare.nhs.uk\/improving-the-quality-of-symptomatic-fit-for-bowel-cancer\/"},{"key":"bibr19-21501319241228161","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp14X682261"},{"key":"bibr20-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.8.2233-2235.1993"},{"key":"bibr21-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258129"},{"key":"bibr22-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2022.e00303"},{"key":"bibr23-21501319241228161","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.10.009"},{"key":"bibr24-21501319241228161","unstructured":"National Institute for Health and Care Excellence. Resource impact report: quantitative faecal immunochemical tests to assess symptomatic people who are at low risk of colorectal cancer in primary care (DG30). 2017 Accessed July 1, 2023. https:\/\/www.nice.org.uk\/guidance\/dg30\/resources\/resource-impact-report-pdf-4540427101"},{"key":"bibr25-21501319241228161","unstructured":"NHS England. 2022\/23 quarterly provider based cancer waiting times statistics. 2023. Accessed September 28, 2023. https:\/\/www.england.nhs.uk\/statistics\/statistical-work-areas\/cancer-waiting-times\/quarterly-prov-cwt\/2022-23-quarterly-provider-based-cancer-waiting-times-statistics\/"}],"container-title":["Journal of Primary Care &amp; Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319241228161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501319241228161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319241228161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:24:27Z","timestamp":1777508667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501319241228161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":25,"alternative-id":["10.1177\/21501319241228161"],"URL":"https:\/\/doi.org\/10.1177\/21501319241228161","relation":{},"ISSN":["2150-1319","2150-1327"],"issn-type":[{"value":"2150-1319","type":"print"},{"value":"2150-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"21501319241228161"}}