{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:12:24Z","timestamp":1790154744251,"version":"4.0.1"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mayo Clinic Division of General Internal Medicine in Rochester"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Prim Care Community Health"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Multicancer Detection (MCD) tests, such as the GRAIL Galleri, offer a novel approach to cancer screening by detecting cancer-specific methylation patterns in cell-free DNA through a single blood sample. This study evaluated an 18-month implementation of MCD testing in a tertiary ambulatory internal medicine clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Between June 2022 and November 2023, 2244 asymptomatic (without symptoms attributed to cancer) patients underwent MCD testing. The study focused on operational workflows, patient and physician education, and diagnostic follow-up of positive results. Standardized materials, including electronic health record (EHR) workflows, FAQs, and diagnostic pathways, were developed to facilitate implementation. Challenges included managing false positives, patient anxiety, costs, and ethical considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 2244 patients tested, 17 (0.76%) had positive results, and 15 underwent further diagnostic evaluation. Cancer was confirmed in 11 (73.3%) patients, including cases of breast, colon, esophageal, lymphoma, ovarian, and pancreatic cancers. Four patients had no identifiable malignancy despite comprehensive work-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MCD testing is feasible in routine clinical workflows, with 73% of positive cases yielding cancer diagnoses. While promising, further research is required to assess long-term outcomes, cost-effectiveness, and optimal implementation strategies of cancer interception in broader healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501319251329290","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:54:28Z","timestamp":1742950468000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Implementation of a Multicancer Detection (MCD) Test in a Tertiary Referral Center in Asymptomatic Patients: An 18-Month Prospective Cohort Study"],"prefix":"10.1177","volume":"16","author":[{"given":"Ryan T.","family":"Hurt","sequence":"first","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya K.","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Dougan","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-391X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Gilman","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R.","family":"Salonen","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Adusumalli","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L.","family":"Bonnes","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl A.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-9502","authenticated-orcid":false,"given":"Amirala S.","family":"Pasha","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Nanda","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4631-4500","authenticated-orcid":false,"given":"Erin M.","family":"Pagel","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina D.","family":"Verness","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Ressler","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jewel J.","family":"Samadder","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-1323","authenticated-orcid":false,"given":"Richard J.","family":"Presutti","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadel A.","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-3934","authenticated-orcid":false,"given":"William","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-3525","authenticated-orcid":false,"given":"Ivana T.","family":"Croghan","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34479"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1366"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1158\/1078-0432.CCR-16-0695","article-title":"Cancer prevention and interception: a new era for chemopreventive approaches","volume":"22","author":"Albini A","year":"2016","unstructured":"Albini A, DeCensi A, Cavalli F, Costa A. Cancer prevention and interception: a new era for chemopreventive approaches. Clin Cancer Res. 2016;22:4322-4327.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_3_5_2","first-page":"639","article-title":"Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer","volume":"73","author":"Ben-Ami R","year":"2024","unstructured":"Ben-Ami R, Wang QL, Zhang J, et al. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer. Gut. 2024;73:639-648.","journal-title":"Gut"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/IGC.0000000000000586","article-title":"Clinical use of cancer biomarkers in epithelial ovarian cancer: updated guidelines from the european group on tumor markers","volume":"26","author":"S\u00f6l\u00e9tormos G","year":"2016","unstructured":"S\u00f6l\u00e9tormos G, Duffy MJ, Othman Abu Hassan S, et al. Clinical use of cancer biomarkers in epithelial ovarian cancer: updated guidelines from the european group on tumor markers. Int J Gynecol Cancer. 2016;26:43-51.","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143501"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1134"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-23-1470"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/09691413241228041"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0140-6736(23)01700-2","article-title":"Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study","volume":"402","author":"Schrag D","year":"2023","unstructured":"Schrag D, Beer TM, McDonnell CH3rd, et al. Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study. Lancet. 2023;402:1251-1260.","journal-title":"Lancet"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2023.107426"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70040","article-title":"Barriers and proposed solutions to at-home colorectal cancer screening tests in medically underserved health centers across three US regions to inform a randomized trial","volume":"13","author":"Brodney S","year":"2024","unstructured":"Brodney S, Bhat RS, Tuan JJ, et al. Barriers and proposed solutions to at-home colorectal cancer screening tests in medically underserved health centers across three US regions to inform a randomized trial. Cancer Med. 2024;13:e70040.","journal-title":"Cancer Med"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1200\/JCO.2023.41.4_suppl.61","article-title":"Association of awareness and use of patient navigation services for colorectal cancer screening with test completion and likelihood of future use","volume":"41","author":"Alam S","year":"2023","unstructured":"Alam S, Zhu X, Squiers L, et al. Association of awareness and use of patient navigation services for colorectal cancer screening with test completion and likelihood of future use. J Clin Oncol. 2023;41:61.","journal-title":"J Clin Oncol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/03008916221133136","article-title":"Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options","volume":"109","author":"Shao SH","year":"2022","unstructured":"Shao SH, Allen B, Clement J, et al. Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options. Tumori J. 2022;109:335-341.","journal-title":"Tumori J"},{"key":"e_1_3_3_16_2","first-page":"4848","article-title":"Cell-free DNA\u2013based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): design of a pragmatic, prospective randomised controlled trial","volume":"14","author":"Neal RD","year":"2022","unstructured":"Neal RD, Johnson P, Clarke CA, et al. Cell-free DNA\u2013based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): design of a pragmatic, prospective randomised controlled trial. Cancers. 2022;14:4848.","journal-title":"Cancers"},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1470-2045(23)00277-2","article-title":"Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study","volume":"24","author":"Nicholson BD","year":"2023","unstructured":"Nicholson BD, Oke J, Virdee PS, et al. Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study. Lancet Oncol. 2023;24:733-743.","journal-title":"Lancet Oncol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","DOI":"10.1093\/jncics\/pkae084","article-title":"Primary care physicians and laypersons\u2019 perceptions of multicancer detection clinical trial designs","volume":"8","author":"Samimi G","year":"2024","unstructured":"Samimi G, Temkin SM, Weil CJ, et al. Primary care physicians and laypersons\u2019 perceptions of multicancer detection clinical trial designs. JNCI Cancer Spectr. 2024;8:pkae084.","journal-title":"JNCI Cancer Spectr"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjmed.2022.03.006","article-title":"Multicancer Early detection Panels (MCEDs) in the primary care setting","volume":"135","author":"Ueberroth BE","year":"2022","unstructured":"Ueberroth BE, Marks LA, Borad MJ, Agrwal N. Multicancer Early detection Panels (MCEDs) in the primary care setting. Am J Med. 2022;135:e145-e149.","journal-title":"Am J Med"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","DOI":"10.31744\/einstein_journal\/2024AO0771","article-title":"Perspectives of primary care providers regarding multicancer early detection panels - einstein (S\u00e3o Paulo)","volume":"22","author":"Ueberroth BE","year":"2024","unstructured":"Ueberroth BE, Presutti RJ, McGary A, et al. Perspectives of primary care providers regarding multicancer early detection panels - einstein (S\u00e3o Paulo). einstein (Sao Paulo). 2024;22:eAO0771.","journal-title":"einstein (Sao Paulo)"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.annonc.2023.02.010","article-title":"Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies","volume":"34","author":"Gao Q","year":"2023","unstructured":"Gao Q, Lin YP, Li BS, et al. Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies. Ann Oncol. 2023;34:486-495.","journal-title":"Ann Oncol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3247"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1158\/1940-6207.CAPR-24-0107","article-title":"Multiyear clinical outcomes of cancers diagnosed following detection by a blood-based multicancer early detection test","volume":"17","author":"Buchanan AH","year":"2024","unstructured":"Buchanan AH, Lennon AM, Choudhry OA, et al. Multiyear clinical outcomes of cancers diagnosed following detection by a blood-based multicancer early detection test. Cancer Prev Res. 2024;17:349-353.","journal-title":"Cancer Prev Res"},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","DOI":"10.1158\/1940-6207.CAPR-23-0451","article-title":"Outcomes following a false-positive multi-cancer early detection test: results from DETECT-A, the first large, prospective, interventional MCED study","volume":"17","author":"Lennon AM","year":"2024","unstructured":"Lennon AM, Buchanan AH, Rego SP, et al. Outcomes following a false-positive multi-cancer early detection test: results from DETECT-A, the first large, prospective, interventional MCED study. Cancer Prev Res. 2024;17:OF1-OF5.","journal-title":"Cancer Prev Res"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1158\/1078-0432.CCR-21-1982","article-title":"EpiPanGI Dx: a cell-free DNA methylation fingerprint for the early detection of gastrointestinal cancers","volume":"27","author":"Kandimalla R","year":"2021","unstructured":"Kandimalla R, Xu J, Link A, et al. EpiPanGI Dx: a cell-free DNA methylation fingerprint for the early detection of gastrointestinal cancers. Clin Cancer Res. 2021;27:6135-6144.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.011"}],"container-title":["Journal of Primary Care &amp; Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319251329290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501319251329290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501319251329290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:23:07Z","timestamp":1777508587000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501319251329290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":25,"alternative-id":["10.1177\/21501319251329290"],"URL":"https:\/\/doi.org\/10.1177\/21501319251329290","relation":{},"ISSN":["2150-1319","2150-1327"],"issn-type":[{"value":"2150-1319","type":"print"},{"value":"2150-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"article-number":"21501319251329290"}}