{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:39:02Z","timestamp":1787855942081,"version":"build-2784847793"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Prim Care Community Health"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Adverse childhood experiences (ACEs) can have lasting effects into adulthood. This study examines the relationship between ACEs and the frequency of substance use among high school students in the United States. Data were drawn from the 2023 Youth Risk Behavior Survey, a nationally representative survey of high school students. A cumulative ACE score was calculated based on 8 self-reported lifetime experiences. Multinomial logistic regression models were used to analyze the association between cumulative ACEs and substance use (alcohol, binge drinking, cannabis, and e-cigarettes). A significant positive association was found between cumulative ACEs and substance use. Higher ACE scores were associated with greater odds of substance use across all categories. Specifically, cumulative ACEs were associated with more frequent alcohol use (OR\u2009=\u20091.89, 95% CI\u2009=\u20091.48, 2.43), binge drinking (OR\u2009=\u20091.69, 95% CI\u2009=\u20091.40, 2.05), cannabis use (OR\u2009=\u20091.81, 95% CI\u2009=\u20091.65, 1.99), and e-cigarette use (OR\u2009=\u20091.89, 95% CI\u2009=\u20091.78, 2.00). Similar results were observed for occasional alcohol use (OR\u2009=\u20091.47, 95% CI\u2009=\u20091.31\u20131.66), binge drinking (OR\u2009=\u20091.53, 95% CI\u2009=\u20091.36\u20131.72), cannabis use (OR\u2009=\u20091.26, 95% CI\u2009=\u20091.01\u20131.57), and e-cigarette use (OR\u2009=\u20091.60, 95% CI\u2009=\u20091.32\u20131.94). This study highlights the significant associations between ACEs and substance use behaviors among adolescents. Addressing ACEs through comprehensive strategies, such as fostering supportive relationships, may be beneficial and promote healthier development.<\/jats:p>","DOI":"10.1177\/21501319251346102","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T05:15:13Z","timestamp":1750137313000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cumulative Adverse Childhood Experiences and Frequency of Substance Use Among US High School Students"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-2841","authenticated-orcid":false,"given":"Sunday","family":"Azagba","sequence":"first","affiliation":[{"name":"The Pennsylvania State University - University Park Campus, College of Nursing, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galappaththige S. 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