{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:43:25Z","timestamp":1777859005148,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Universidad Espiritu Santo Ecuador"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Prim Care Community Health"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The hypertriglyceridemic-waist phenotype (HTWP), defined by concurrent hypertriglyceridemia and increased waist circumference, is a recognized marker of metabolic and cardiovascular risk. While extensively studied across populations, data on Amerindian communities remain scarce. This study examines HTWP prevalence and its association with type 2 diabetes mellitus in middle-aged and older adults of Amerindian ancestry in rural Ecuador.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This population-based cross-sectional study was conducted in 3 ethnically homogeneous villages. Participants aged \u226540\u2009years underwent standardized assessments, including structured interviews and fasting blood tests. HTWP was defined using serum triglyceride levels \u2265150\u2009mg\/dL together with increased waist circumference determined by 2 criteria: Amerindian-specific (men\u2009\u2265\u200989\u2009cm, women \u226583\u2009cm) and NCEP-ATP III (men \u2265102\u2009cm, women \u226588\u2009cm). Logistic regression models assessed associations between HTWP and diabetes indicators, adjusting for demographics and cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 1354 participants, HTWP prevalence was 47% by Amerindian-specific, and 30% using NCEP-ATP III criteria. Hypertriglyceridemia was frequent (55%), particularly in men. In multivariate models, HTWP was associated with fasting glucose \u2265126\u2009mg\/dL under both Amerindian-specific (OR 1.32, 95% CI 1.02-1.71) and NCEP-ATP III (OR 1.50, 95% CI 1.12-2.01) criteria. When HTWP components were separately included in the models, only hypertriglyceridemia remained significantly associated with diabetes risk. No significant association was observed between HTWP and HbA1c levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HTWP prevalence is high in this population. Hypertriglyceridemia drives diabetes risk more than waist circumference. Findings underscore the need for ethnicity-specific cardiovascular risk assessments and targeted health interventions for indigenous communities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501319251362044","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T10:53:40Z","timestamp":1753959220000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of hypertriglyceridemic-waist phenotype and its association with type 2 diabetes mellitus among middle-aged and older adults of Amerindian ancestry"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-7572","authenticated-orcid":false,"given":"Denisse A.","family":"Rumbea","sequence":"first","affiliation":[{"name":"Universidad Esp\u00edritu Santo\u2014Ecuador, Samborond\u00f3n, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robertino M.","family":"Mera","sequence":"additional","affiliation":[{"name":"Biostatistics\/Epidemiology, Freenome, Inc., South San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio E.","family":"Arias","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo\u2014Ecuador, Samborond\u00f3n, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber","family":"Arriaga","sequence":"additional","affiliation":[{"name":"Clinical Laboratory UEESBiolab Universidad Esp\u00edritu Santo\u2014Ecuador, Samborond\u00f3n, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-8805","authenticated-orcid":false,"given":"Oscar H.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo\u2014Ecuador, Samborond\u00f3n, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01945-6"},{"key":"e_1_3_2_3_2","article-title":"Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology?","volume":"23","author":"Lemieux I","year":"2007","unstructured":"Lemieux I, Poirier P, Bergeron J, et al. 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