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We developed and piloted PrEP-Pro, an intervention to support family medicine residents to prescribe HIV pre-exposure prophylaxis (PrEP), with a focus on AGYW. We pilot-tested the intervention, evaluating feasibility, acceptability, and appropriateness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using intervention mapping, we developed sexual history training, PrEP curricula, and a PrEP champion program. For the 6-month pilot test, we trained PrEP champions who trained and supported residents at their sites. Participating physicians completed enrollment and exit questionnaires capturing PrEP provision experiences, attitudes\/skills\/barriers to completing a sexual history, and PrEP knowledge\/attitudes\/beliefs. Exit questionnaires assessed PrEP-Pro acceptability, feasibility, and appropriateness. We compared enrollment and exit scores on sexual history assessment, PrEP knowledge, and provider behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 46 participants (median age\u2009=\u200929\u2009years), 57% were men, 59% were White, 15% were Asian, 11% were Latinx, and 7% were Black. Among 32 (70%) participants completing both enrollment and exit questionnaires, we observed significant increases in sexual history skills, PrEP knowledge, and PrEP attitudes, and non-significant increases in the proportion reporting routine sexual history assessment and HIV testing. On a 5-point scale, feasibility (mean 4.28 (SD\u2009=\u20090.42), acceptability (4.31 (0.53)), and appropriateness (4.25 (0.46)) scores were high with respect to the PrEP-Pro intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This multi-component intervention was feasible, acceptable, and appropriate for family medicine residents in the pilot. Pre- and post-evaluation suggest participation in the intervention increased PrEP knowledge and improved sexual history-taking. These findings suggest that the intervention could successfully enhance provider self-efficacy in delivering sexual health care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501319251398356","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:15:41Z","timestamp":1764591341000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Theory Informed Multi-Component Intervention to Promote Family Medicine Provider PrEP Prescription to Adolescent Girls and Young Women in the U.S. Southeast: Pilot Trial Results"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-6328","authenticated-orcid":false,"given":"Lynn T.","family":"Matthews","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-0401","authenticated-orcid":false,"given":"Madeline C.","family":"Pratt","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseyi O.","family":"Isehunwa","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian M.","family":"Klasen","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha V.","family":"Hill","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"},{"name":"Children\u2019s Healthcare of Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Simpson","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-8363","authenticated-orcid":false,"given":"Brook A.","family":"Hubner","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-5271","authenticated-orcid":false,"given":"Nicholas","family":"Van Wagoner","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-4141","authenticated-orcid":false,"given":"Robin Gaines","family":"Lanzi","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[{"name":"Montgomery Family Medicine Residency Program, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3716-8311","authenticated-orcid":false,"given":"Trupti","family":"Nadkar","sequence":"additional","affiliation":[{"name":"Montgomery Family Medicine Residency Program, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Malhotra","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham \u2013 Huntsville Medical, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas S.","family":"Krakower","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara E.","family":"Wood","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-4481","authenticated-orcid":false,"given":"Dustin M.","family":"Long","sequence":"additional","affiliation":[{"name":"Wake Forest University, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latesha E.","family":"Elopre","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"HIV.gov. 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