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As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20\u2009mg\/day for over 1\u2009year, which she stopped 1\u2009week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50\u2009mg\/day. Without remission of symptoms, methotrexate 15\u2009mg\/week was initiated.<\/jats:p>","DOI":"10.1177\/21501327211028714","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T09:20:01Z","timestamp":1625304001000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Statin-Induced Autoimmune Necrotizing Myopathy"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0830-1866","authenticated-orcid":false,"given":"Sahani","family":"Jayatilaka","sequence":"first","affiliation":[{"name":"Reading Hospital, West Reading, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Desai","sequence":"additional","affiliation":[{"name":"Reading Hospital, West Reading, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarup","family":"Rijal","sequence":"additional","affiliation":[{"name":"Reading Hospital, West Reading, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Reading Hospital, West Reading, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"bibr1-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-11-248"},{"key":"bibr2-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70601-6"},{"issue":"5","key":"bibr3-21501327211028714","first-page":"e7963","volume":"12","author":"Stroie OP","year":"2020","journal-title":"Cureus"},{"key":"bibr4-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.09.023"},{"key":"bibr5-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801936"},{"issue":"44","key":"bibr6-21501327211028714","first-page":"748","volume":"112","author":"Laufs U","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"bibr7-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv043"},{"key":"bibr8-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1177\/1545968305277167"},{"key":"bibr9-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2286"},{"key":"bibr10-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.22.2671"},{"key":"bibr11-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.07.001"},{"key":"bibr12-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450010075034"},{"key":"bibr13-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180111"},{"key":"bibr14-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180110"},{"key":"bibr15-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004923"},{"key":"bibr16-21501327211028714","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005694"}],"container-title":["Journal of Primary Care &amp; Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501327211028714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501327211028714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501327211028714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:22:52Z","timestamp":1777508572000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501327211028714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":16,"alternative-id":["10.1177\/21501327211028714"],"URL":"https:\/\/doi.org\/10.1177\/21501327211028714","relation":{},"ISSN":["2150-1319","2150-1327"],"issn-type":[{"value":"2150-1319","type":"print"},{"value":"2150-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"21501327211028714"}}