{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:18:10Z","timestamp":1784762290669,"version":"3.55.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p> An ideal material for repair of congenitally malformed hearts would encourage tissue regeneration with growth potential. Decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) promotes tissue regeneration in animal models and noncardiac human applications. This retrospective review evaluates SIS-ECM for reconstruction of congenital heart defects. From June 2007 to May 2009, SIS-ECM patches were used in 43 operations on 40 patients aged 2 days to 13 years. In 16 cases, the SIS-ECM was used for pericardial closure. The SIS-ECM was used for cardiac or great vessel repair in 37 cases: atrial septal defect repair in 11, pulmonary arterioplasty in 10, right ventricular outflow tract patch in 6, pulmonary monocusp valve creation in 5, superior vena cava patch in 2 and aortoplasty in 2, valve leaflet augmentation in 2, and repair of unroofed coronary sinus in 1. Follow-up was complete. There were 5 deaths, all unrelated to the SIS-ECM. Mean follow-up was 7.85 months (0.5-24 months). No pericardial effusions or intracardiac or intravascular thromboses occurred related to the SIS-ECM. The patches did not shrink or calcify. Four of 5 monocusp valves were competent and none were stenotic. One patient who underwent tricuspid valve anterior leaflet augmentation with SIS-ECM required tricuspid valve replacement 4 months later for severe regurgitation following a catheter-based procedure. Explanted tissue showed resorption of the SIS-ECM, replacement with organized collagen, and re-endothelialization. Repair of congenital heart defects using SIS-ECM is feasible and safe. In valve reconstruction, this procedure shows potential for replacement by autologous tissue. Longer-term follow-up is required to assess the potential for growth. <\/jats:p>","DOI":"10.1177\/2150135110362092","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T21:32:02Z","timestamp":1271194322000},"page":"132-136","source":"Crossref","is-referenced-by-count":101,"title":["Preliminary Experience With Cardiac Reconstruction Using Decellularized Porcine Extracellular Matrix Scaffold: Human Applications in Congenital Heart Disease"],"prefix":"10.1177","volume":"1","author":[{"given":"Frank G.","family":"Scholl","sequence":"first","affiliation":[{"name":"The Cardiac Center, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Boucek","sequence":"additional","affiliation":[{"name":"The Cardiac Center, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kak-Chen","family":"Chan","sequence":"additional","affiliation":[{"name":"The Cardiac Center, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilliam","family":"Valdes-Cruz","sequence":"additional","affiliation":[{"name":"The Cardiac Center, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Perryman","sequence":"additional","affiliation":[{"name":"The Cardiac Center, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"bibr1-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401869200"},{"key":"bibr2-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.3.734"},{"key":"bibr3-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.04.043"},{"key":"bibr4-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.03.002"},{"key":"bibr5-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)00436-X"},{"key":"bibr6-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1177\/155335060501200307"},{"key":"bibr7-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/1\/1\/R01"},{"key":"bibr8-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.003"},{"key":"bibr9-2150135110362092","doi-asserted-by":"crossref","unstructured":"Rehman J, Li J, Orschell CM, March KL. Peripheral blood \u201cendothelial progenitor cells\u201d are derived from monocyte\/macrophages and secrete angiogenic growth factors. Circulation 2003;107:1164\u20131169.","DOI":"10.1161\/01.CIR.0000058702.69484.A0"},{"key":"bibr10-2150135110362092","first-page":"278","volume":"15","author":"Kasimir MT","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"bibr11-2150135110362092","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10104375"},{"key":"bibr12-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70073-7"},{"key":"bibr13-2150135110362092","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.10062"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135110362092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135110362092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135110362092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:53:09Z","timestamp":1740963189000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135110362092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/2150135110362092"],"URL":"https:\/\/doi.org\/10.1177\/2150135110362092","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}