{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:08:29Z","timestamp":1774289309471,"version":"3.50.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Development of a subaortic membrane is not fully understood. Recurrence after surgical removal continues to be high. We sought to assess the differences in aorto-septal angles (AoSA) to possibly explain alterations within the left ventricular outflow tract, hence in subaortic membrane formation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 113 patients who underwent subaortic membrane resection were matched by age and sex with 113 controls. The subaortic membrane resection group included isolated subaortic membranes (n = 34, group I), associated with ventricular septal defect (n = 29, group II), or patent ductus arteriosus (n = 50, group III). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Mean (\u00b1 standard deviation) AoSA (in degrees) were not different between subaortic membrane groups I, II, and III but were steeper than their control groups (126.2 \u00b1 9.2 vs 138.6 \u00b1 7.0, 129.2 \u00b1 9.9 vs 137.7 \u00b1 10.0, and 126.2 \u00b1 8.1 vs 135 \u00b1 8.5, respectively; all Ps &lt; .05). Additionally, group II had lower preoperative gradients (28.8 \u00b1 20.7 mm Hg) compared to groups I and III (67.0 \u00b1 32.9 and 66.2 \u00b1 33.1 mm Hg, respectively, P &lt; .001). Follow-up ranged from 3 to 132 months. In 22 (32%) patients, a subaortic membrane recurred. Early postoperative residual gradients and development of aortic regurgutation were associated with the need for reoperation ( P &lt; .05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> These findings suggest a contributing role of the AoSA in the development of subaortic membrane. Further rheological experiments are warranted. Whether the steeper the angle the higher the risk of recurrence may be revealed by longer follow-up periods. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2150135113485760","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T05:56:33Z","timestamp":1372917393000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Subaortic Membrane and Aorto-Septal Angle"],"prefix":"10.1177","volume":"4","author":[{"given":"Laura A.","family":"Barboza","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Unidad de Cirug\u00eda Cardiovascular de Guatemala\u2013UNICAR, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor de Maria","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Unidad de Cirug\u00eda Cardiovascular de Guatemala\u2013UNICAR, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquin","family":"Barnoya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Unidad de Cirug\u00eda Cardiovascular de Guatemala\u2013UNICAR, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Leon-Wyss","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Unidad de Cirug\u00eda Cardiovascular de Guatemala\u2013UNICAR, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo R.","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Unidad de Cirug\u00eda Cardiovascular de Guatemala\u2013UNICAR, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"bibr1-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01241-2"},{"key":"bibr2-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1974.tb03241.x"},{"key":"bibr3-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.08.034"},{"key":"bibr4-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.01.095"},{"key":"bibr5-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00180-8"},{"key":"bibr6-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.6.708"},{"key":"bibr7-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00048-X"},{"key":"bibr8-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38945-7"},{"key":"bibr9-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90005-3"},{"key":"bibr10-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90287-W"},{"key":"bibr11-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.01.016"},{"key":"bibr12-2150135113485760","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427043"},{"issue":"5","key":"bibr13-2150135113485760","first-page":"II159","volume":"88","author":"van 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