{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:46Z","timestamp":1777918606345,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Previous studies reporting on tumor necrosis factor-\u03b1 (TNF-\u03b1) as a marker of inflammatory response (IR) in patients with congenital heart disease were limited by small sample size and variability in diagnosis. We report perioperative changes in TNF-\u03b1 levels and their correlation with preoperative factors and clinical outcomes in a large homogenous group of patients with tetralogy of Fallot (TOF) undergoing definitive repair at a tertiary care center. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 167 patients were divided into four groups on the basis of age. Group 1 included infants less than 1 year, group 2 included children between 1 and 12 years, group 3 included adolescents between 12 and 18 years, and group 4 included adults more than 18 years of age. Serum TNF-\u03b1 levels were measured at three time points and correlated with perioperative variables. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The baseline TNF-\u03b1 level correlated with patients\u2019 nutritional status and degree of cyanosis in all four groups. The magnitude of IR in the postcardiopulmonary bypass (post-CPB) period as measured by TNF-\u03b1 level was much higher and correlated more consistently with adverse clinical outcomes in the younger age group (groups 1 and 2). On multivariable analysis; age at operation, preoperative degree of hypoxemia and TNF-\u03b1 levels were found to be independent predictors of clinical outcomes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> We demonstrated a rise in serum TNF-\u03b1 levels in patients with TOF undergoing definitive repair on CPB, which correlated with preoperative severity of cyanosis, nutritional status, and adverse clinical outcomes. The TNF-\u03b1 levels may be monitored to identify cyanotic patients at an increased risk of exhibiting augmented IR to CPB. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2150135113507290","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T21:58:45Z","timestamp":1389218325000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Perioperative Levels of Tumor Necrosis Factor-\u03b1 Correlate With Outcomes in Children and Adults With Tetralogy of Fallot Undergoing Corrective Surgery"],"prefix":"10.1177","volume":"5","author":[{"given":"Brijindera Singh","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Cardiac Anesthesiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam Malhotra","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujjwal K.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minati","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"bibr1-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199310001-00006"},{"key":"bibr2-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199208000-00004"},{"key":"bibr3-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00931-9"},{"key":"bibr4-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70306-9"},{"key":"bibr5-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-0934-y"},{"key":"bibr6-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f333aa"},{"key":"bibr7-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)91007-A"},{"key":"bibr8-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009470"},{"key":"bibr9-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.124391"},{"key":"bibr10-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34848-2"},{"issue":"5","key":"bibr11-2150135113507290","first-page":"174","volume":"76","author":"Del Nido PJ","year":"1987","journal-title":"Circulation"},{"key":"bibr12-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00477-7"},{"key":"bibr13-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03391-4"},{"key":"bibr14-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00536-8"},{"key":"bibr15-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.2.187"},{"key":"bibr16-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199712)173:3<335::AID-JCP5>3.0.CO;2-O"},{"key":"bibr17-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1136\/adc.60.12.1134"},{"key":"bibr18-2150135113507290","first-page":"32403","author":"Yilmaz E","year":"2007","journal-title":"Mediat Inflamm"},{"key":"bibr19-2150135113507290","first-page":"76","volume":"450","author":"WHO child growth standards based on length\/height, weight and age","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"bibr20-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1038\/320584a0"},{"key":"bibr21-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90090-J"},{"key":"bibr22-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.5.356"},{"key":"bibr23-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.12.055"},{"key":"bibr24-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.6.1476"},{"key":"bibr25-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.037"},{"key":"bibr26-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000078574.76915.11"},{"key":"bibr27-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.073"},{"key":"bibr28-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.5.1233"},{"key":"bibr29-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-4081-7"},{"key":"bibr30-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00682.x"},{"key":"bibr31-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.6.1706"},{"key":"bibr32-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80551-3"},{"key":"bibr33-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1159\/000244428"},{"key":"bibr34-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00018"},{"key":"bibr35-2150135113507290","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh172"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135113507290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135113507290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135113507290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T01:54:09Z","timestamp":1738029249000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135113507290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/2150135113507290"],"URL":"https:\/\/doi.org\/10.1177\/2150135113507290","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}