{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:14:00Z","timestamp":1758474840007,"version":"3.38.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> We sought to evaluate the mid-term results of a repair-oriented strategy of the aortic valve in children. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Between February 2007 and November 2011, we performed 39 aortic valve repairs in children. Median age and weight at surgery were 5.5 years (3 days-18 years) and 16.7 kg (2.7-83.5), respectively. A total of 11 (28%) patients had one or more prior surgical or interventional cardiologic procedures. Median intensive care unit and hospital stay were two (1-96) and five (3-96) days, respectively. Median and cumulative follow-up were 12.7 months (15 days-64 months) and 48.9 patient-years, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> There were 3 (7.7%) early deaths all in patients undergoing additional complex cardiac procedures. Two (5.1%) patients required early surgical revision. Twenty-six (66%) patients had isolated or mixed aortic stenosis. The median gradient reduced from 62.4 (range 16-144) to 17.6 mm Hg (range 0-51.8), postoperatively ( P = .02). At last follow-up, the median gradient remained largely unchanged at 21.1 mm Hg (0-49; P = .02). Twenty-six (66%) patients had isolated or mixed aortic valve regurgitation (mild in 8 [20%], moderate in 15 [38%], and severe in 6 ([15%] patients). The degree of aortic regurgitation improved in all patients with moderate or severe aortic regurgitation ( P = .04). At last follow-up, two patients had moderate aortic regurgitation. Kaplan Meier freedom from reintervention in the survivors was 95% at three years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> A repair-oriented strategy for the aortic valve in children has satisfactory early and mid-term results and remains a promising management option in children with aortic valve disease. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2150135113513476","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T18:55:44Z","timestamp":1395773744000},"page":"191-199","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of a Repair-Oriented Strategy for the Aortic Valve in Children"],"prefix":"10.1177","volume":"5","author":[{"given":"Pramod","family":"Kandakure","sequence":"first","affiliation":[{"name":"Cardiac Surgical Unit, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Prior","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Unit, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giri","family":"Soda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Dhannapuneni","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Unit, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Unit, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Alphonso","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Cardiac Service, Mater Children\u2019s Hospital, Raymond Terrace, South Brisbane 4101, 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