{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:07:23Z","timestamp":1771304843558,"version":"3.50.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Hyperoxemic management during cardiopulmonary bypass (CPB) is still common, and there is no consensus about physiologic oxygen tension strategy (normoxemic management) during pediatric CPB. In this study, we compared the postoperative conditions and measures of inflammatory response among patients with acyanotic congenital heart disease subjected to either hyperoxemic or normoxemic management strategy during CPB. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We studied 22 patients with a ventricular septal defect and pulmonary artery hypertension. The patients were divided into two groups. Group I (n = 9) received normoxemic management (PaO<jats:sub>2<\/jats:sub> = 100-150 mm Hg) and group II (n = 13) received hyperoxemic management (PaO<jats:sub>2<\/jats:sub> = 200-300 mm Hg) during CPB. There was no difference between groups with regard to age, body weight, duration of CPB, and aorta clamping time or preoperative pulmonary hypertension (pulmonary pressure\/systemic pressure [Pp\/Ps]). In each group, the blood samples to measure the cytokine levels were collected before and after the CPB. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Although we observed no statistically significant differences in postoperative intubation time, alveolar\u2013arterial oxygen difference, creatine kinase MB level, and pulmonary hypertension (Pp\/Ps) between group I (10.7 \u00b1 13.4 hours, 197 \u00b1 132 mm Hg, 148 \u00b1 58.6 IU\/L, 42.8% \u00b1 22.1%, respectively) and group II (27.8 \u00b1 36.5 hours, 227 \u00b1 150 mm Hg, 151 \u00b1 72.6 IU\/L, 50.4% \u00b1 16.0%, respectively), levels of median interleukin 6 and tumor necrosis factor \u03b1 were lower in group I (129.8 and 17.0 pg\/mL, respectively) than that in group II (487.8 and 22.5 pg\/mL, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> During the CPB in acyanotic pediatric patients, normoxemic management can minimize the systemic inflammatory response syndrome associated with CPB. We can apply this physiologic oxygen tension strategy to surgical advantage during heart surgeries in acyanotic pediatric patients. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2150135114551029","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T18:20:44Z","timestamp":1413483644000},"page":"541-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Inflammatory Response to Hyperoxemic and Normoxemic Cardiopulmonary Bypass in Acyanotic Pediatric Patients"],"prefix":"10.1177","volume":"5","author":[{"given":"Hiroshi","family":"Kagawa","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyozo","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Kinouchi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"bibr1-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.124142"},{"key":"bibr2-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70134-5"},{"key":"bibr3-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00905-3"},{"key":"bibr4-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.08.036"},{"key":"bibr5-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70007-2"},{"key":"bibr6-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70011-0"},{"key":"bibr7-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70002-1"},{"key":"bibr8-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198911000-00011"},{"key":"bibr9-2150135114551029","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.6.2280"},{"issue":"3","key":"bibr10-2150135114551029","first-page":"861","volume":"73","author":"Hiramatsu 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