{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:06:50Z","timestamp":1777878410242,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Literature on the use of nicardipine, a dihydropyridine calcium channel antagonist, in children recovering from cardiac surgery is sparse and, to our knowledge, nonexistent in children with single ventricle anatomy. We aimed to report our experience with nicardipine in these patient populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective review of children recovering from aortic coarctectomy or superior cavopulmonary anastomoses who received nicardipine for hypertension at our institution between 2007 and 2013. Hemodynamic variables prior to and after nicardipine initiation were compared using paired t tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seven children recovering from aortic coarctectomy (median age 8.6 months, range: 1.5 months-7.9 years) and four children recovering from superior cavopulmonary anastomosis (median age: seven months, range: five-nine months) were reviewed. For all patients, at six hours after initiation of nicardipine, mean systolic blood pressure was significantly decreased, 123 \u00b1 19 versus 103 \u00b1 14 mm Hg ( P = .001), as were diastolic blood pressure, 68 \u00b1 20 versus 53.5 \u00b1 10 mm Hg ( P = .041), and sodium nitroprusside dose, 4.3 \u00b1 2.9 versus 1.3 \u00b1 1.7 mcg\/kg\/min ( P = .002). Further, within 24 hours, serum lactate decreased from 1.45 \u00b1 0.82 to 0.81 \u00b1 0.29 mg\/dL ( P = .016). Heart rate, blood urea nitrogen, and serum creatinine measurements were statistically unchanged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Nicardipine effectively decreased blood pressure without apparent adverse events in a small cohort of children with postoperative hypertension while recovering from aortic coarctectomy or superior cavopulmonary anastomosis. Further research comparing nicardipine to more conventional titratable antihypertensive agents in these patient populations is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135115608815","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T12:43:13Z","timestamp":1451392993000},"page":"32-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Nicardipine for Hypertension Following Aortic Coarctectomy or Superior Cavopulmonary Anastomosis"],"prefix":"10.1177","volume":"7","author":[{"given":"Christopher W.","family":"Mastropietro","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Riley Hospital of Children, in affiliation with Indiana University, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Arango Uribe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Michigan, in affiliation with Wayne State University, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"bibr1-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)66683-0"},{"key":"bibr2-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.3.382"},{"issue":"5","key":"bibr3-2150135115608815","first-page":"II149","volume":"88","author":"Chang AC","year":"1993","journal-title":"Circulation"},{"key":"bibr4-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00582-8"},{"key":"bibr5-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70371-X"},{"key":"bibr6-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.086"},{"key":"bibr7-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L192"},{"key":"bibr8-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000383"},{"key":"bibr9-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1007\/BF01953981"},{"key":"bibr10-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200101000-00002"},{"key":"bibr11-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0497-0"},{"key":"bibr12-2150135115608815","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666130-00010"},{"key":"bibr13-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199107000-00018"},{"key":"bibr14-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000074908.17214.FD"},{"key":"bibr15-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70063-X"},{"key":"bibr16-2150135115608815","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0739-8"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135115608815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135115608815","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135115608815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:19:38Z","timestamp":1777591178000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135115608815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1177\/2150135115608815"],"URL":"https:\/\/doi.org\/10.1177\/2150135115608815","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]}}}