{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:07:43Z","timestamp":1777878463048,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Homozygous familial hypercholesterolemia (HoFH; Fredrickson IIa) is a rare autosomal dominant hereditary disease associated with increased low-density lipoprotein cholesterol. We hereby report anesthetic challenges in a rare case of HoFH having severe progressive aortic stenosis, mitral regurgitation, diffuse aortic and carotid vessel involvement, and severe left ventricular dysfunction. The patient underwent a Konno aortoventriculoplasty with mechanical prosthesis along with mitral valve repair.<\/jats:p>","DOI":"10.1177\/2150135117702127","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T08:06:33Z","timestamp":1506499593000},"page":"NP83-NP87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Homozygous Familial Hypercholesterolemia: Anesthetic Challenges and Review of Literature"],"prefix":"10.1177","volume":"11","author":[{"given":"Suruchi","family":"Ladha","sequence":"first","affiliation":[{"name":"Department of Cardiac Anesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeti","family":"Makhija","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudheer K","family":"Aarav","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"bibr1-2150135117702127","first-page":"2863","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Goldstein JL","year":"2001","edition":"8"},{"key":"bibr2-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.04.003"},{"key":"bibr3-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.019"},{"issue":"89","key":"bibr4-2150135117702127","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.0954-6820.1938.tb19279.x","volume":"95","author":"M\u00fcller C","year":"1938","journal-title":"Acta Med Scandinav"},{"key":"bibr5-2150135117702127","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S8283"},{"key":"bibr6-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"bibr7-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.077"},{"key":"bibr8-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00456-5"},{"key":"bibr9-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.160408"},{"key":"bibr10-2150135117702127","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3282f3f499"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135117702127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135117702127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135117702127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:20:45Z","timestamp":1777591245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135117702127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/2150135117702127"],"URL":"https:\/\/doi.org\/10.1177\/2150135117702127","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}