{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:17:58Z","timestamp":1791901078460,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Boston Children\u2019s Hospital Office of Faculty Development, Research Recruitment and Resource Committee, and Clinical and Translational Research Executive Committee","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiac rehabilitation (CR) improves exercise capacity and quality of life while reducing mortality in adults with acquired heart disease. Cardiac rehabilitation has not been extensively studied in adults with congenital heart disease (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We performed a prospective, randomized controlled trial (NCT01822769) of a 12-week clinical CR program compared with standard of care (SOC). Participants were \u226516 years old, had moderate or severe CHD, had O\n                      <jats:sub>2<\/jats:sub>\n                      saturation \u226592%, and had peak O\n                      <jats:sub>2<\/jats:sub>\n                      consumption ([Formula: see text]) &lt; 80% predicted. We assessed exercise capacity, physical activity, quality of life, self-reported health status, and other variables at baseline and after 12 weeks. The prespecified primary end point was change in [Formula: see text].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We analyzed data on 28 participants (aged 41.1 \u00b1 12.1 years, 50% male), 13 randomized to CR and 15 to SOC. [Formula: see text] averaged 16.8 \u00b1 3.8 mL\/kg\/min, peak work rate = 95 \u00b1 28 W, and median Minnesota Living with Heart Failure Questionnaire (MLHFQ) score = 27 (interquartile range: 11-44). Cardiac rehabilitation participants were older (48 \u00b1 9 years vs 36 \u00b1 12 years; P = .01), but there were no significant between-group differences in other variables. There were no adverse events related to CR. [Formula: see text] increased in the CR group compared with SOC (+2.2 mL\/kg\/min, 95% confidence interval: 0.7-3.7; P = .002, age-adjusted +2.7 mL\/kg\/min; P = .004); there was a nonsignificant improvement in work rate (+8.1 W; P = .13). Among the 25 participants with baseline MLHFQ &gt; 5, there was a clinically important &gt;5-point improvement in 72.7% and 28.6% of CR and SOC participants, respectively ( P = .047). Cardiac rehabilitation was also associated with improved self-assessment of overall health ( P &lt; .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cardiac rehabilitation is safe and is associated with improvement in aerobic capacity and self-reported health status compared with SOC in adults with CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135117752123","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:43:30Z","timestamp":1521161010000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["A Randomized Trial Comparing Cardiac Rehabilitation to Standard of Care for Adults With Congenital Heart Disease"],"prefix":"10.1177","volume":"9","author":[{"given":"Alexander R.","family":"Opotowsky","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Landzberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami B.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri M.","family":"Shafer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen DeFaria","family":"Yeh","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Crouter","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Recreation, and Sport Studies, The University of Tennessee, Knoxville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ubeda Tikkanen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Cardiovascular Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"bibr1-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.166"},{"key":"bibr2-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.058719"},{"key":"bibr3-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123310"},{"key":"bibr4-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2013.09.012"},{"key":"bibr5-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e32808621b9"},{"key":"bibr6-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00280.x"},{"key":"bibr7-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.9.1069"},{"key":"bibr8-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.10.011"},{"key":"bibr9-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.044"},{"key":"bibr10-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.701466"},{"issue":"6","key":"bibr11-2150135117752123","first-page":"685","volume":"19","author":"Therrien J","year":"2003","journal-title":"Can J Cardiol"},{"key":"bibr12-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00370.x"},{"key":"bibr13-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.036"},{"key":"bibr14-2150135117752123","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr396"},{"key":"bibr15-2150135117752123","unstructured":"ACHA ACHD Program Criteria. 2016. https:\/\/www.achaheart.org\/media\/1487\/acha-achd-program-criteria-final-7116.pdf. 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