{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:51:46Z","timestamp":1780548706815,"version":"3.54.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The role of steroids to mitigate the deleterious effects of pediatric cardiopulmonary bypass (CPB) remains a matter of debate; therefore, we aimed to assess preferences in administering corticosteroids (CSs) and the use of other anti-inflammatory strategies in pediatric cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 19-question survey was distributed to consultants in pediatric cardiac anesthesia from 12 centers across the United Kingdom and Ireland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 37 respondents (37\/60, 62%), 24 (65%) use CSs, while 13 (35%) do not use steroids at all. We found variability within 5 (41%) of the 12 centers. Seven consultants (7\/24, 29%) administer CSs in every case, while 17 administer CSs in selected cases only (17\/24, 71%). There was variability in the dose of steroid administration. Almost all consultants (23\/24, 96%) administer a single dose at induction, and one administers a two-dose regimen (1\/24, 4%). There was variability in CS indications. Most consultants (24\/37, 66%) use modified ultrafiltration at the conclusion of CPB. Fifteen consultants (15\/32, 47%) report the use of aprotinin, while only 3 use heparin-coated circuits (3\/24, 9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We found wide variability in practice in the administration of CSs for pediatric cardiac surgery, both within and between units. While most anesthetists administer CSs in at least some cases, there is no consensus on the type of steroid, the dose, and at which patient groups this should be directed. Modified ultrafiltration is still used by most of the centers. Almost half of consultants use aprotinin, while heparin-coated circuits are infrequently used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135118762392","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T06:16:19Z","timestamp":1524636979000},"page":"289-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Corticosteroids and Other Anti-Inflammatory Strategies in Pediatric Heart Surgery: A National Survey of Practice"],"prefix":"10.1177","volume":"9","author":[{"given":"Daniel P.","family":"Fudulu","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Bristol Heart Institute, Bristol, United Kingdom"},{"name":"Henry Welcome Laboratories for Integrative Neuroscience and Metabolism, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Schadenberg","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Anesthesia and Intensive Care, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gibbison","sequence":"additional","affiliation":[{"name":"Cardiac Anesthesia and Intensive Care, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Anesthesia and Intensive Care, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stafford","family":"Lightman","sequence":"additional","affiliation":[{"name":"Henry Welcome Laboratories for Integrative Neuroscience and Metabolism, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni D.","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bristol Heart Institute, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Stoica","sequence":"additional","affiliation":[{"name":"Department of Congenital Cardiac Surgery, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"issue":"4","key":"bibr1-2150135118762392","first-page":"I86","volume":"33","author":"Replogle RL","year":"1966","journal-title":"Circulation"},{"key":"bibr2-2150135118762392","doi-asserted-by":"crossref","unstructured":"Laffey JG, Boylan JF, Cheng DCH. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology. 2002;97(1):215\u2013252. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12131125. Accessed April 5, 2017.","DOI":"10.1097\/00000542-200207000-00030"},{"key":"bibr3-2150135118762392","first-page":"150","volume-title":"Kirklin. Barratt-Boyes Cardiac Surgery","author":"Kouchoukos N","year":"2012"},{"key":"bibr4-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01082-1"},{"key":"bibr5-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0827-x"},{"key":"bibr6-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.11.059"},{"key":"bibr7-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.02.013"},{"key":"bibr8-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000566"},{"key":"bibr9-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000063443.32874.60"},{"key":"bibr10-2150135118762392","unstructured":"Toledo-Pereyra LH, Lin CY, Kundler H, Replogle RL. Steroids in heart surgery: a clinical double-blind and randomized study. Am Surg. 1980;46(3):155\u2013160. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7377659."},{"key":"bibr11-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.08.042"},{"key":"bibr12-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2016.07.003"},{"key":"bibr13-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.11.005"},{"key":"bibr14-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000426"},{"key":"bibr15-2150135118762392","unstructured":"STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery (STRESS). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03229538. Published July 25 2017. Updated December 18 2017. Accessed February 22, 2018."},{"key":"bibr16-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.948737"},{"key":"bibr17-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2034"},{"key":"bibr18-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032089"},{"key":"bibr19-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F177"},{"key":"bibr20-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.12.013"},{"key":"bibr21-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283532d12"},{"key":"bibr22-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000773"},{"key":"bibr23-2150135118762392","doi-asserted-by":"crossref","unstructured":"Langley SM, Chai PJ, Jaggers JJ, Ungerleider RM. Preoperative high dose methylprednisolone attenuates the cerebral response to deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 2000;17(3):279\u2013286. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10758389.","DOI":"10.1016\/S1010-7940(00)00336-5"},{"key":"bibr24-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000180206.95542.76"},{"key":"bibr25-2150135118762392","unstructured":"CCAS News\u2014The Congenital Cardiac Anesthesia Society Newsletter. http:\/\/www2.ccasociety.org\/newsletters\/2010summer\/ccanetwork.html. Published April 2010. Accessed January 10, 2018."},{"key":"bibr26-2150135118762392","unstructured":"6.3.2 Glucocorticoid therapy: British National Formulary. https:\/\/www.evidence.nhs.uk\/formulary\/bnf\/current\/6-endocrine-system\/63-corticosteroids\/632-glucocorticoid-therapy. Published 2017. Updated 2018. Accessed May 26, 2017."},{"key":"bibr27-2150135118762392","unstructured":"CCAD\u2014Congenital Analysis\u2014Summary Data\u2014By Year. https:\/\/nicor4.nicor.org.uk\/chd\/an_paeds.nsf\/WSummaryYears?openview&RestrictToCategory=2015&start=1&count=500. Published April 2016. Updated November 24, 2016. Accessed April 28, 2017."},{"key":"bibr28-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181a3105d"},{"key":"bibr29-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000163678.20704.C5"},{"key":"bibr30-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000541"},{"key":"bibr31-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-1059-3"},{"key":"bibr32-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001180"},{"key":"bibr33-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70331-4"},{"key":"bibr34-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.04.019"},{"key":"bibr35-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1097\/01.mat.0000183473.93237.10"},{"key":"bibr36-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112450061"},{"key":"bibr37-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1177\/0267659116668245"},{"key":"bibr38-2150135118762392","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12312"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135118762392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135118762392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135118762392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:21:25Z","timestamp":1777591285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135118762392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1177\/2150135118762392"],"URL":"https:\/\/doi.org\/10.1177\/2150135118762392","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]}}}