{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:08:37Z","timestamp":1777878517706,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Current technology advances in virtual surgery modeling and computational flow dynamics allow preoperative individualized computer-based design of Fontan operation. To determine potential role of those innovations in patients undergoing hepatic vein incorporation (HVI) following Kawashima operation, we retrospectively examined historic cohort of patients who underwent HVI following Kawashima with focus on regression of pulmonary arteriovenous malformations (PAVMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two children with single ventricle and interrupted inferior vena cava underwent Kawashima operation (2002-12). Twenty-one (96%) patients had left atrial isomerism and 21 (96%) had undergone prior first-stage palliation. Clinical outcomes were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean O\n                      <jats:sub>2<\/jats:sub>\n                      saturation (SaO\n                      <jats:sub>2<\/jats:sub>\n                      ) increased from 77% \u00b1 8% to 85% \u00b1 6% ( P = .002) after Kawashima. Fifteen (68%) patients developed PAVMs. Eighteen patients underwent HVI (median age and interval from Kawashima: 4.4 and 3.7 years, respectively). Mean SaO\n                      <jats:sub>2<\/jats:sub>\n                      prior to HVI was 77% \u00b1 8% and increased to 81% \u00b1 10% at the time of hospital discharge ( P = .250), with five patients requiring home oxygen. On follow-up, mean SaO\n                      <jats:sub>2<\/jats:sub>\n                      increased to 95% \u00b1 4% ( P &lt; .001). Overall ten-year survival following Kawashima was 94%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      A large number of patients develop PAVMs and subsequent cyanosis after Kawashima operation. Early following HVI, SaO\n                      <jats:sub>2<\/jats:sub>\n                      is commonly low and insignificantly different from that prior to HVI. Although SaO\n                      <jats:sub>2<\/jats:sub>\n                      will improve on follow-up in most patients, a number of patients continue to have low saturations, indicating incomplete resolution of PAVMs. Given the heterogeneity of those patients and lack of preoperative predictors for complete PAVM regression, our findings suggest a role for virtual surgery to determine optimal individual procedure design that would provide even distribution of hepatic blood flow to both pulmonary arteries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135118809082","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T14:43:15Z","timestamp":1547044995000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes of Single Ventricle Patients Undergoing the Kawashima Procedure: Can We Do Better?"],"prefix":"10.1177","volume":"10","author":[{"given":"Bahaaldin","family":"Alsoufi","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University of Louisville, Norton Children\u2019s Hospital, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Children\u2019s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Travers","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Children\u2019s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Trusty","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit P.","family":"Yoganathan","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Slesnick","sequence":"additional","affiliation":[{"name":"Sibley Heart Center, Children\u2019s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"bibr1-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr280"},{"key":"bibr2-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.017"},{"issue":"17","key":"bibr3-2150135118809082","first-page":"1","author":"Jacobs JP","year":"2007","journal-title":"Cardiol Young"},{"key":"bibr4-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.01.054"},{"key":"bibr5-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37445-8"},{"key":"bibr6-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.04.043"},{"key":"bibr7-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00665-7"},{"key":"bibr8-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.05.101"},{"issue":"4","key":"bibr9-2150135118809082","first-page":"1011","volume":"40","author":"Setyapranata S","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"bibr10-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.045"},{"key":"bibr11-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.06.114"},{"key":"bibr12-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr091"},{"key":"bibr13-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr003"},{"key":"bibr14-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00450-8"},{"key":"bibr15-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1217"},{"key":"bibr16-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.309"},{"key":"bibr17-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.115423"},{"key":"bibr18-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00852-0"},{"key":"bibr19-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00011-3"},{"key":"bibr20-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00961-7"},{"key":"bibr21-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00494-4"},{"key":"bibr22-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.032"},{"key":"bibr23-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.015"},{"key":"bibr24-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0442-8"},{"key":"bibr25-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.cad.2015.06.018"},{"key":"bibr26-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.03.019"},{"key":"bibr27-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0614-4"},{"key":"bibr28-2150135118809082","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.11.060"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135118809082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135118809082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135118809082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:21:57Z","timestamp":1777591317000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135118809082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/2150135118809082"],"URL":"https:\/\/doi.org\/10.1177\/2150135118809082","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}