{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:09:06Z","timestamp":1777878546669,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children with Down syndrome (DS) often have congenital heart disease that requires surgical repair in the first year. Anecdotally, we have noted that patients with DS seem to have a higher rate of culture-negative postoperative fever. The objective was to evaluate the prevalence of postoperative fever and recovery among patients with DS undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective, case\u2013control study of all patients at our institution less than one year of age with DS undergoing surgical repair of an atrioventricular septal defect or ventricular septal defect between 2010 and 2016. The control group was patients with no chromosomal anomalies who were age and surgery matched to the DS group. Temperatures were recorded for the first 72 hours postoperatively, with duration and degree of fever being assessed using the area under the curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with DS (n = 34) had a significantly higher prevalence of fever than the control group (59% vs 24%, P = .003), longer ventilator time, and longer length of stay. Among the DS group, those who developed fever tended to be older at the time of surgery (146 \u00b1 63 vs 103 \u00b1 45 days, P = .04). The DS group with fever had similar cardiopulmonary bypass times, intensive care unit and total lengths of stay, ventilator days, and hospital costs compared to patients with DS without fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with DS have a higher incidence of culture-negative fever within the first 72 hours. The presence of fever in these patients, however, does not affect their overall postoperative course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135119864575","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T08:00:38Z","timestamp":1568016038000},"page":"599-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Culture-Negative Fever in Infants With Down Syndrome Undergoing Cardiac Surgery"],"prefix":"10.1177","volume":"10","author":[{"given":"Jeffrey","family":"Vergales","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, University of Virginia, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-5723","authenticated-orcid":false,"given":"Michael D.","family":"Seckeler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, University of Arizona, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Chew","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Vanderbilt University, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"bibr1-2150135119864575","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8"},{"key":"bibr2-2150135119864575","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.03.009"},{"key":"bibr3-2150135119864575","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900483"},{"key":"bibr4-2150135119864575","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9625-4"},{"key":"bibr5-2150135119864575","doi-asserted-by":"crossref","unstructured":"Cooney TP, Thurlbeck WT. 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