{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:25:06Z","timestamp":1782987906092,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Published palliation outcomes of infants with functional single ventricle (SV) and common atrioventricular septal defect (AVSD) are poor due to associated cardiac and extracardiac anomalies and development of atrioventricular valve (AVV) regurgitation. We report current palliation results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From 2002 to 2012, 80 infants with functional SV with AVSD underwent multistage palliation. Competing-risks analyses modeled events after first-stage surgery and Glenn (death\/transplantation vs next palliation surgery) and examined factors associated with survival and AVV intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-eight (80%) patients received neonatal palliation: modified Blalock-Taussig shunt (n = 33, 41%), Norwood (n = 20, 25%), and pulmonary artery band (n = 15, 19%), whereas 12 (15%) received primary Glenn. On competing-risks analysis, one-year following first-stage surgery, 29% of patients had died or received transplantation and 62% had undergone Glenn. Five years following Glenn, 9% of patients had died or received transplantation and 68% had undergone Fontan. Overall eight-year survival was 64% and was lower in patients with genetic syndromes (53% vs 82%), patients requiring concomitant total anomalous pulmonary venous connection repair (53% vs 69%), and those requiring neonatal palliation (48% vs 100%). Factors associated with mortality were unplanned reoperation (hazard ratio [HR]: 3.7 [1.7-8.0], P = .001) and extracorporeal membrane oxygenation use (HR: 7.1 [3.0-16.6], P &lt; .001). Initial AVV regurgitation \u2265 moderate was associated with AVV intervention (HR: 6.2 [2.4-16.1], P = .002) with eight-year freedom from death or AVV intervention of 25% in those patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with SV with AVSD are a distinct group and commonly have associated cardiac and extracardiac malformations that complicate care and affect survival. The development of AVV regurgitation requiring intervention is common but does not affect survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135119885890","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T23:39:07Z","timestamp":1576280347000},"page":"39-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes of Multistage Palliation of Infants With Single Ventricle and Atrioventricular Septal Defect"],"prefix":"10.1177","volume":"11","author":[{"given":"Bahaaldin","family":"Alsoufi","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University of Louisville and Norton Children\u2019s Hospital, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"McCracken","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Emory University and Children\u2019s Healthcare of Atlanta, Druid Hills, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Kanter","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Emory University and Children\u2019s Healthcare of Atlanta, Druid Hills, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Shashidharan","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Emory University and Children\u2019s Healthcare of Atlanta, Druid Hills, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Border","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Emory University and Children\u2019s Healthcare of Atlanta, Druid Hills, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kogon","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"bibr1-2150135119885890","unstructured":"Ferencz C, Loffredo CA, Correa-Villasenor A, Wilson PD. 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