{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:11Z","timestamp":1787504411077,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI090959"],"award-info":[{"award-number":["AI090959"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiac transplantation in early childhood is limited by scarcity of organ donors. Advances in cardiac xenotransplantation (XTx) research suggest that xenografts may one day represent an alternative to allografts. We sought to determine the attitudes among surgeons and cardiologists in the field of pediatric cardiac transplantation toward the potential use of XTx if this clinical option were to become a reality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A Likert-scale anonymous survey addressing the use of XTx in pediatric patients was sent to members of the Congenital Heart Surgeons (CHS) Society and the Pediatric Heart Transplant Society. Results were described and compared between the two surgeon\/physician groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ninety-two CHS and 42 pediatric transplant cardiologists (PTC) responded (N = 134). The potential acceptance of XTx was high in both groups, assuming risks and results were similar to those of cardiac allotransplantation (88% CHS vs 81% PTC;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .07). When asked if they would recommend a xenograft, if the results were anticipated to be inferior to those of cardiac allotransplantation, as a bridge to a human heart, potential acceptance fell dramatically but remained higher among CHS than PTC (41% vs 17%, p 0.02). Approximately only one-third of CHS and half of PTC preferred primary cardiac XTx for hypoplastic left heart syndrome if there was no waitlist time and had similar outcomes to allotransplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings suggest that potential acceptance of XTx by CHS and PTC would not be a major barrier if XTx demonstrated similar outcomes to allotransplantation. Acceptance by other congenital heart stakeholders remains to be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135120916744","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T06:11:03Z","timestamp":1594102263000},"page":"426-430","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Attitudes to Cardiac Xenotransplantation by Pediatric Heart Surgeons and Physicians"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-044X","authenticated-orcid":false,"given":"Luz A.","family":"Padilla","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Sorabella","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar F.","family":"Carlo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Dabal","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Paris","sequence":"additional","affiliation":[{"name":"Department of Social Work, Abilene Christian University, Abilene, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Scientific Registry of Transplant Recipients. 2017 annual data report: heart. Funding from the Health Resources and Services Administrator. Minneapolis MN: Hennepin Healthcare Research Institute. Published 2017. Accessed 18 December 2019 https:\/\/srtr.transplant.hrsa.gov\/annual_reports\/2017\/Heart.aspx."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.01.07"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.001377"},{"issue":"19","key":"e_1_3_3_5_2","first-page":"31452","article-title":"Anti-pig antibody in infants: can a genetically engineered pig heart bridge to allotransplantation?","volume":"0003","author":"Li Q","year":"2019","unstructured":"Li Q, Hara H, Banks A, et al. Anti-pig antibody in infants: can a genetically engineered pig heart bridge to allotransplantation? Ann Thorac Surg. 2019:S0003\u20134975(19)31452\u20133. doi:org\/10.1016\/j.athoracsur.2019.08.061.","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_3_6_2","first-page":"217","article-title":"Xenotransplantation: the challenge to current psychosocial attitudes","volume":"10","author":"Appel JZ","year":"2000","unstructured":"Appel JZ, Alwayn IPJ, Cooper DKC. Xenotransplantation: the challenge to current psychosocial attitudes. J Transplant Coord. 2000;10:217\u2013223.","journal-title":"J Transplant Coord"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/soc4.12022"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2009.00578.x"},{"key":"e_1_3_3_9_2","unstructured":"Congenital Heart Surgeons\u2019 Society. Membership directory. Accessed 28 November 2018 https:\/\/chss.org\/directory.cgi."},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"e12583","DOI":"10.1111\/xen.12583","article-title":"Meta-analysis of public perception toward xenotransplantation","author":"Mitchell C","year":"2020","unstructured":"Mitchell C, Lipps A, Padilla L, Werkheiser Z, Cooper DKC, Paris W. Meta-analysis of public perception toward xenotransplantation. Xenotransplantation. 2020:e12583. doi:10.1111\/xen.12583.","journal-title":"Xenotransplantation"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12400"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2012.11928783"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029375"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.194"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00125"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0163278718807744"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0016-z"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135120916744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135120916744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135120916744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:23:09Z","timestamp":1777591389000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135120916744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/2150135120916744"],"URL":"https:\/\/doi.org\/10.1177\/2150135120916744","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}