{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:02:17Z","timestamp":1793444537754,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to describe our experience with patients with sickle cell trait (SCT) and undergoing surgery on cardiopulmonary bypass (CPB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data on all patients with SCT or sickle-\u03b1 thalassemia who underwent surgery on CPB were collected (1996-2017).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 46 patients were included, 37 (80%) had SCT and 9 (20%) had sickle-\u03b1 thalassemia. A total of 4 (9%) developed a potential sickle cell\u2013related complication. Patients with sickle cell-related complications were significantly older (median 14 years vs 14 months, P = .037) and heavier (median 54 kg vs 9 kg, P = .041). Complications occurred, although without statistical significance, in patients who underwent longer median CPB times (249 minutes vs 137 minutes, P = .069), lower median temperature (31.7 \u00b0C vs 33.3 \u00b0C, P = .094), and a higher percentage underwent deep hypothermic circulatory arrest (50% vs 7%, P = .053). A total of 30 (65%) patients underwent exchange transfusion (ET) pre-bypass. Patients who underwent ET were significantly older (median 4 years vs 7 months, P = .003) and heavier (median 16 kg vs 6 kg, P = .015) than patients who did not undergo ET. The incidence of complications was comparable between patients who underwent ET (10%) and those who did not (6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this retrospective, single-center study, it has been shown that cardiac surgery requiring CPB in patients with SCT and sickle-\u03b1 thalassemia had a low risk for sickle cell-associated complications. In this cohort of patients, older age, longer CPB times, lower median temperature, and the utilization of deep hypothermic circulatory arrest appear to play an important role in the development of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2150135120926991","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T16:21:44Z","timestamp":1598545304000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Sickle Cell-Related Complications in Patients Undergoing Cardiopulmonary Bypass"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4842-4008","authenticated-orcid":false,"given":"Martin A.","family":"Chacon-Portillo","sequence":"first","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad B.","family":"Mossad","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiovascular Anesthesia, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Zea-Vera","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Beckerman","sequence":"additional","affiliation":[{"name":"Texas Center for Pediatric and Congenital Heart Disease, University of Texas Dell Medical School\/Dell Children\u2019s Medical Center, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad M.","family":"Binsalamah","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iki","family":"Adachi","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Mery","sequence":"additional","affiliation":[{"name":"Texas Center for Pediatric and Congenital Heart Disease, University of Texas Dell Medical School\/Dell Children\u2019s Medical Center, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Heinle","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Charles D.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Texas Center for Pediatric and Congenital Heart Disease, University of Texas Dell Medical School\/Dell Children\u2019s Medical Center, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"issue":"1","key":"bibr1-2150135120926991","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ajh.21550","volume":"85","author":"Ballas SK","year":"2010","journal-title":"Am J Hematol"},{"key":"bibr2-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21883"},{"key":"bibr3-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370040409"},{"issue":"49","key":"bibr4-2150135120926991","first-page":"1155","volume":"63","author":"Ojodu J","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr5-2150135120926991","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2013.832689"},{"key":"bibr6-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12787"},{"key":"bibr7-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006110"},{"key":"bibr8-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06006.x"},{"key":"bibr9-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2007.00527.x"},{"key":"bibr10-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1177\/021849230601400113"},{"key":"bibr11-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00038-1"},{"issue":"4","key":"bibr12-2150135120926991","first-page":"283","volume":"26","author":"Sutton SW","year":"1999","journal-title":"Tex Heart Inst J"},{"key":"bibr13-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830130106"},{"key":"bibr14-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"issue":"1","key":"bibr15-2150135120926991","first-page":"7","volume":"91","author":"Aliyu ZY","year":"2006","journal-title":"Haematologica"},{"key":"bibr16-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.01.057"},{"key":"bibr17-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2004.07.032"},{"key":"bibr18-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.58"},{"key":"bibr19-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13093"},{"key":"bibr20-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.882464"},{"key":"bibr21-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu249"},{"key":"bibr22-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15021"},{"key":"bibr23-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(67)90288-8"},{"key":"bibr24-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-6296(89)97891-5"},{"issue":"3","key":"bibr25-2150135120926991","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1213\/00000539-199909000-00010","volume":"89","author":"Djaiani GN","year":"1999","journal-title":"Anesth Analg"},{"key":"bibr26-2150135120926991","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.7.486"},{"issue":"10","key":"bibr27-2150135120926991","first-page":"1269","volume":"45","author":"Ohashi Y","year":"1996","journal-title":"Masui"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135120926991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2150135120926991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2150135120926991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:23:15Z","timestamp":1777591395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2150135120926991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/2150135120926991"],"URL":"https:\/\/doi.org\/10.1177\/2150135120926991","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]}}}