{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:49:47Z","timestamp":1789562987064,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although considering the pathophysiology of post-coarctectomy hypertension, \u03b2-blockers should be effective, experience with labetalol for treatment is limited in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective collection and analysis of data in children aged \u22646 years following coarctectomy in our tertiary care university medical center between January 2009 and June 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>96 patients were included, 45 were treated with intravenous labetalol and 51 received no treatment. Median time to maximum dose received (median 1.1 mg\/kg\/h) was 2.7 h, and median time to the reduction of labetalol dose was 8.3 h. No antihypertensives had to be added. In one child, labetalol was switched to nitroprusside due to bronchoconstriction. Of patients receiving intravenous labetalol, 48% had been switched to oral labetalol at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravenous labetalol is a fast, effective, and safe drug to treat hypertension following aortic coarctation repair. Labetalol is easily converted to oral therapy when the continuation of treatment is considered necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351221111797","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T02:36:35Z","timestamp":1666838195000},"page":"701-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Post-Coarctectomy Hypertension With Labetalol\u2014A 9-Year Single-Center Experience"],"prefix":"10.1177","volume":"13","author":[{"given":"Carolien","family":"Siersma","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-9114","authenticated-orcid":false,"given":"Carole N. M.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Sojak","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend D. J.","family":"Ten Harkel","sequence":"additional","affiliation":[{"name":"Willem Alexander Children\u2019s Hospital \u2013 Division of Pediatric Cardiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-9408","authenticated-orcid":false,"given":"Peter P.","family":"Roeleveld","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"bibr1-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.086"},{"key":"bibr2-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.04.129"},{"key":"bibr3-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1177\/2150135117690104"},{"key":"bibr4-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1349-z"},{"key":"bibr5-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.05.027"},{"key":"bibr6-21501351221111797","unstructured":"The Dutch Paediatric Formulary\u2014Dutch Paediatric Pharmacotherapy Expertise Network (NKFK). Accessed December 20, 2021. https:\/\/www.kinderformularium.nl\/geneesmiddel\/425\/labetalol"},{"key":"bibr7-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.06.035"},{"key":"bibr8-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000075557.41987.A3"},{"key":"bibr9-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505093121904"},{"key":"bibr10-21501351221111797","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90930-6"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501351221111797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501351221111797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501351221111797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:24:48Z","timestamp":1777591488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501351221111797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/21501351221111797"],"URL":"https:\/\/doi.org\/10.1177\/21501351221111797","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]}}}