{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:10:58Z","timestamp":1777878658245,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Background: Unrepaired truncus arteriosus (TA) carries poor prognosis due to complications of unrestricted pulmonary flow, truncal valve insufficiency, and pulmonary vascular disease. Currently, the hemodynamic profile of adults late after TA repair is unknown. We reviewed the hemodynamics, prevalence, and pathophysiology of pulmonary hypertension (PH) in this population. Methods: Eighteen adult patients with repaired TA who underwent cardiac catheterization at Mayo Clinic, MN, between 1997 and 2021 were identified. PH was defined as either precapillary (mean pulmonary artery pressure [mPAP] \u226525\u2005mm\u2005Hg, pulmonary artery wedge pressure [PAWP] \u226415\u2005mm\u2005Hg, and pulmonary vascular resistance [PVR] &gt;3 Wood units), isolated postcapillary (mPAP \u226525, PAWP &gt;15, PVR \u22643), or combined (mPAP \u226525, PAWP &gt;15, and PVR &gt;3). Diastolic pressure and transpulmonary gradients were used as ancillary data for classification. Results: Mean age at catheterization was 34\u2009\u00b1\u200910 years. Mean right ventricular (RV) systolic pressure was 82\u2009\u00b1\u200922.6\u2005mm\u2005Hg, mean right and left mPAPs 28.1\u2009\u00b1\u200916.2 and 27.9\u2009\u00b1\u200911.9\u2005mm\u2005Hg, respectively. Seven patients (41.2%) had PAWP &gt;15\u2005mm\u2005Hg and, among those undergoing arterial catheterization, 7 (53.8%) had a left ventricular (LV) end-diastolic pressure &gt;15\u2005mm\u2005Hg. PH was diagnosed in 13 patients (72.2%): 6 (33.3%) precapillary, 4 (22.2%) isolated postcapillary, and 3 (16.7%) combined. PAWP &gt;15\u2005mm\u2005Hg was associated with male sex ( P\u2009=\u2009.049), &lt;moderate RV dysfunction ( P\u2009=\u2009.049), and lesser RV conduit mean systolic gradient ( P\u2009=\u2009.02). Patients with PH with precapillary component were older at catheterization ( P\u2009=\u2009.046). Conclusions: In adults with repaired TA, precapillary PH was only present in one-third of patients with mPAPs not significantly increased in most, whereas elevated PAWP and left-heart disease were common.<\/jats:p>","DOI":"10.1177\/21501351221114779","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T02:36:35Z","timestamp":1666838195000},"page":"716-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Repair of Truncus Arteriosus: A Long-Term Hemodynamic Assessment"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-1608","authenticated-orcid":false,"given":"Irene","family":"Mart\u00edn de Miguel","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Charles","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C.","family":"Egbe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 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