{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:11:09Z","timestamp":1777878669975,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The adequacy of tissue O\n                      <jats:sub>2<\/jats:sub>\n                      delivery in infants receiving intensive care is difficult to measure directly. Regional O\n                      <jats:sub>2<\/jats:sub>\n                      (rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) and fractional tissue O\n                      <jats:sub>2<\/jats:sub>\n                      extraction (FTOE), the ratio of O\n                      <jats:sub>2<\/jats:sub>\n                      consumption to O\n                      <jats:sub>2<\/jats:sub>\n                      delivery, obtained from newer noninvasive tools, such as near-infrared spectroscopy (INVOS) and microvascular tissue oximetry (T-Stat) can provide important information on the adequacy of tissue oxygenation and aid in managing critically ill infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We prospectively evaluated differences in rSO\n                      <jats:sub>2<\/jats:sub>\n                      and FTOE in 26 infants with hypoplastic left heart syndrome (HLHS) (n\u2009=\u200912) or d-transposition of the great arteries (d-TGA) (n\u2009=\u200914). Continuous noninvasive monitoring of SpO\n                      <jats:sub>2<\/jats:sub>\n                      , heart rate, and perfusion index with pulse oximetry, cerebral-rSO\n                      <jats:sub>2<\/jats:sub>\n                      and renal-rSO\n                      <jats:sub>2<\/jats:sub>\n                      with INVOS, and buccal tissue oxygenation using T-Stat were performed during immediate postoperative period for 24 hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The SpO\n                      <jats:sub>2<\/jats:sub>\n                      and rSO\n                      <jats:sub>2<\/jats:sub>\n                      in infants with d-TGA were higher compared with the infants with HLHS at all measured sites (buccal mucosa, cerebral, and renal). Significant regional differences were also observed in FTOE across all infants with the highest at the buccal mucosa tissue level, followed by cerebral and renal measurement sites. As compared with infants with d-TGA, infants with HLHS had higher regional FTOE and heart rate, with a lower arterial O\n                      <jats:sub>2<\/jats:sub>\n                      content and perfusion index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study demonstrates the utility of noninvasive hemodynamic monitoring to assess regional oxygenation and perfusion, as evidenced by significant differences in infants with HLHS and d-TGA, conditions with different circulation physiologies. Such comprehensive monitoring can potentially aid in evaluating treatment strategies aimed at preventing organ damage from O\n                      <jats:sub>2<\/jats:sub>\n                      insufficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351221141425","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:00:34Z","timestamp":1670821234000},"page":"194-200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Noninvasive Monitoring to Demonstrate Postoperative Differences in Regional Hemodynamics in Newborn Infants With d-Transposition of the Great Arteries and Hypoplastic Left Heart Syndrome"],"prefix":"10.1177","volume":"14","author":[{"given":"Prateek V","family":"Sahni","sequence":"first","affiliation":[{"name":"Division of Neonatology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganga","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Sahni","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"bibr1-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"bibr2-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019881"},{"key":"bibr3-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.045"},{"key":"bibr4-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.04.098"},{"key":"bibr5-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.102749"},{"key":"bibr6-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2650-1"},{"key":"bibr7-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.07.020"},{"key":"bibr8-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.06.012"},{"key":"bibr9-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00439.x"},{"key":"bibr10-21501351221141425","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.03.008"},{"issue":"1","key":"bibr11-21501351221141425","first-page":"S60e9","volume":"6","author":"Vretzakis 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