{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:11:27Z","timestamp":1777878687113,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Objective: We reviewed our experience with transvenous liver biopsy-derived hepatic fibrosis scores and possible associated risk factors in those postextracardiac Fontan patients. Methods: We identified extracardiac-Fontan patients with postoperative durations &lt;20 years who underwent cardiac catheterizations with transvenous hepatic biopsies between April 2012 and July 2022. If a patient underwent two liver biopsies, we averaged the two total fibrosis scores and concurrent time, pressure, and oxygen saturation data. We grouped patients by the following factors: (1) sex, (2) venovenous collaterals, and (3) type of functionally univentricular heart. We identified potential hepatic fibrosis risk factors as the following: female, presence of venovenous collaterals, and a functional univentricle of right-ventricular type. For statistical analysis, we used Kruskal-Wallis nonparametric testing. Results: We identified 127 patients who underwent 165 transvenous biopsies, with 38 patients undergoing 2 biopsies. We found that females with two additional risk factors had the highest median total fibrosis scores, 4 (1-8); males with &lt;2 risk factors had the lowest median total fibrosis scores, 2 (0-5); and females with &lt;2 additional risk factors and males with two risk factors were in the middle, median total fibrosis score 3 (0-6), P =.002; and there were no statistical differences for the other demographic or hemodynamic variables. Conclusions: For extracardiac-Fontan patients with similar demographic and hemodynamic variables, identifiable risk factors are associated with the degree of hepatic fibrosis.<\/jats:p>","DOI":"10.1177\/21501351231154216","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T02:20:31Z","timestamp":1678242031000},"page":"345-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic Fibrosis Risk Factors in Extracardiac-Fontan Patients: Observations From a Single Center"],"prefix":"10.1177","volume":"14","author":[{"given":"William N","family":"Evans","sequence":"first","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben J","family":"Acherman","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Galindo","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Rothman","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L","family":"Ciccolo","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Department of Surgery, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lehoux","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-5787","authenticated-orcid":false,"given":"Humberto","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Congenital Heart Center Nevada, Las Vegas, NV, USA"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"bibr1-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696"},{"key":"bibr2-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.02.016"},{"key":"bibr3-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00504.x"},{"key":"bibr4-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4614-x"},{"key":"bibr5-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2004-6_3"},{"key":"bibr6-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.05.006"},{"key":"bibr7-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0315-7"},{"key":"bibr8-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14375"},{"key":"bibr9-21501351231154216","doi-asserted-by":"publisher","DOI":"10.2174\/1566524016666161004143613"},{"key":"bibr10-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160131"},{"key":"bibr11-21501351231154216","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i6.310"},{"key":"bibr12-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.063"},{"key":"bibr13-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.016"},{"key":"bibr14-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.16880"},{"key":"bibr15-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14951"},{"key":"bibr16-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12276"},{"key":"bibr17-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1177\/2150135120969388"},{"key":"bibr18-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15553"},{"key":"bibr19-21501351231154216","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.021"},{"key":"bibr20-21501351231154216","unstructured":"Said S, Marey G. 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