{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:59:40Z","timestamp":1778878780630,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R184-2014- 2478"],"award-info":[{"award-number":["R184-2014- 2478"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Objective: The surgical treatment of malformed semilunar valves in congenital heart defects is challenging in terms of providing both longevity and the potential to grow with the recipient. We investigated a new surgical technique \u201cTrileaflet Semilunar Valve Reconstruction\u201d in an acute porcine model, a technique with geometrical properties that could remain sufficient and allow for some growth with the child. Methods: An acute 60-kg porcine model was used. With echocardiography, baseline pulmonary valvular geometry and hemodynamics were investigated. On cardiopulmonary bypass, the pulmonary leaflets were explanted, and the Trileaflet Semilunar Valve Reconstruction was performed with customized homograft-treated pericardial neo-leaflets. Off bypass, hemodynamics was reassessed. Results: Twelve animals were investigated. The neo-valves were found sufficient in ten animals and with minimal regurgitation in two animals. The neo-valve had a peak gradient of 3\u2009\u00b1\u20092 mm Hg with a peak velocity of 0.8\u2009\u00b1\u20090.2\u2005m\/s. The coaptation in the neo-valve had a mean increase of 4\u2009\u00b1\u20093\u2005mm, P\u2009&lt;\u2009.001. The neo-valve had a windmill shape in the echocardiographic short-axis view, and the neo-leaflets billowed at the annular plane in the long-axis view. Conclusions: In this acute porcine model, the neo-valve had no clinically significant regurgitation or stenosis. The neo-valve had an increased coaptation, a windmill shape, and leaflets that billowed at the annular plane. These geometric findings may allow for sustained sufficiency as the annular and pulmonary artery dimension increase with the child's growth. Further long-term studies should be performed to evaluate the efficacy and the growth potential.<\/jats:p>","DOI":"10.1177\/21501351231166662","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T07:57:52Z","timestamp":1681199872000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Trileaflet Semilunar Valve Reconstruction: Acute Porcine in Vivo Evaluation"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-8195","authenticated-orcid":false,"given":"Lisa Carlson","family":"Hanse","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell Juan","family":"Tj\u00f8rnild","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarmiga","family":"Karunanithi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Viborg Regional Hospital, Viborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"H\u00f8gfeldt Jedrzejczyk","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Islamagi\u010d","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nynne Emilie","family":"Hummelsh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene","family":"Enevoldsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Lugones","sequence":"additional","affiliation":[{"name":"Centro de Ciencias Naturais e Humanas, Universidade Federal do ABC, Santo Andr\u00e9, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"H\u00f8j Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke Elisabeth","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-9525","authenticated-orcid":false,"given":"Ignacio","family":"Lugones","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery, Hospital General de Ni\u00f1os \u201cDr Pedro de Elizalde\u201d, Buenos Aires, 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