{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:11:57Z","timestamp":1777878717854,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Objectives: To examine the probability of left ventricular outflow tract (LVOT) reintervention following interrupted aortic arch (IAA) repair in neonates with LVOT obstruction (LVOTO) risk. Methods: This retrospective multicenter study included 150 neonates who underwent IAA repair (2003-2017); 100 of 150 (67%) had isolated IAA repair (with ventricular septal defect closure) and 50 of 150 (33%) had concomitant LVOT intervention: conal muscle resection (n\u2009=\u200916), Ross-Konno (n\u2009=\u20097), and Yasui operation (n\u2009=\u200927: single-stage n\u2009=\u20098, staged n\u2009=\u200919). Demographic and morphologic characteristics were reviewed. Factors associated with LVOT reoperation were explored using multivariable analysis. Results: Concomitant LVOT intervention was more likely in neonates with type B IAA, bicuspid aortic valve, aberrant right subclavian artery, smaller aortic valve annulus, and ascending aorta dimensions. On follow-up, five-year freedom from LVOT reoperation was highest following Ross-Konno (100%), 77% following Yasui (mainly for neo-aortic regurgitation), 77% following isolated IAA repair (mainly for LVOTO), and 47% following IAA repair with concomitant conal resection, P\u2009=\u2009.033. While all patients had low peak LVOT gradient at time of discharge, those who had conal resection developed higher gradients on follow-up ( P\u2009=\u2009.007). Ross-Konno and Yasui procedures were associated with higher right ventricular outflow tract (RVOT) reoperation. In the cohort following isolated IAA repair, aortic sinus Z score was associated with LVOT reoperation. Conclusions: Both Yasui and Ross-Konno operations effectively mitigate late LVOTO risk. The highest risk of reintervention for LVOTO was associated with conal muscle resection while the lowest risk is associated with Ross-Konno. The RVOT reoperation risk in patients who had Ross-Konno or Yasui does not seem to affect survival.<\/jats:p>","DOI":"10.1177\/21501351241236742","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T18:32:13Z","timestamp":1721932333000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Fate of the Left Ventricular Outflow Tract Following Interrupted Aortic Arch Repair"],"prefix":"10.1177","volume":"15","author":[{"given":"Shuhua","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Schoof","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, UMC Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Hickey","sequence":"additional","affiliation":[{"name":"Texas Children's Heart Institute, Texas Children's Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conall","family":"Morgan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-9644","authenticated-orcid":false,"given":"Nina A.","family":"Korsuize","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, UMC Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heynric B.","family":"Grotenhuis","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, UMC Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Mertens","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaymie","family":"Varenbut","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi Xiaoming","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-6723","authenticated-orcid":false,"given":"Maruti","family":"Haranal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Border","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen Van","family":"Arsdell","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, UCLA Mattel 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