{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:12:24Z","timestamp":1777878744760,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We sought to determine the management and early outcomes of complete atrioventricular septal defect\u2014tetralogy of Fallot (AVSD-TOF) for a contemporary multicenter cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 739 participants in the Congenital Heart Surgeons' Society AVSD cohort (January 2012-May 2021), 40 had AVSD-TOF. We first compared survival differences for patients with AVSD-TOF versus those with isolated AVSD using propensity matching. Secondly, for patients with AVSD-TOF, we compared staged (n\u2009=\u200916) versus primary (n\u2009=\u200924) repair by assessing the following: patient characteristics, progression of atrioventricular valve (AVV) regurgitation, and time-related reoperation and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five-year survival was similar between matched AVSD-TOF and isolated AVSD groups (80% vs 81%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.9). Compared with primary repair patients, staged patients had smaller pulmonary valve annulus Z-score measured at first presentation (\u22122.2 vs \u22122.9,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.006). All staged patients (12 Blalock-Thomas-Taussig shunts, 3 right-ventricular-outflow-tract stents, 1 ductal stent) survived to complete repair. Freedom from AVSD-related reoperation five years post-AVSD-TOF repair was 57% after staged versus 90% after primary repair (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) and left AVV reoperations were the most frequent reintervention. Survival five years after AVSD-TOF repair was 80% (63% after staged vs 90% after primary repair;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing AVSD-TOF repair have similar survival compared with matched isolated AVSD patients. Although approximately half of AVSD-TOF patients had initial palliation and all survived to complete repair, staged repair patients had lower survival and a higher reintervention rate compared with primary repair patients. The decision to pursue staged versus primary repair for future babies with AVSD-TOF remains challenging and should be chosen based on individual circumstances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351241293158","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:36:44Z","timestamp":1732163804000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Outcomes for Management of Atrioventricular Septal Defect\u2014Tetralogy of Fallot in the Last Decade: A Congenital Heart Surgeons\u2019 Society Study"],"prefix":"10.1177","volume":"16","author":[{"given":"Connor P.","family":"Callahan","sequence":"first","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-2203","authenticated-orcid":false,"given":"Madison B.","family":"Argo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin Hospital and Clinics, Madison, WI, USA"},{"name":"Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"McCrindle","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-5337","authenticated-orcid":false,"given":"David J.","family":"Barron","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anusha","family":"Jegatheeswaran","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, UK"},{"name":"Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osami","family":"Honjo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios C.","family":"Polimenakos","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Congenital Cardiac Surgery, Children\u2019s Hospital of Georgia, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Turek","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke Children\u2019s Hospital, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Dabal","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-3267","authenticated-orcid":false,"given":"James K.","family":"Kirklin","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-225X","authenticated-orcid":false,"given":"William M.","family":"DeCampli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiac Surgery, Arnold Palmer Hospital for Children, Orlando, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirooz","family":"Eghtesady","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery, St. Louis Children\u2019s Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Overman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Children\u2019s Hospital and Clinics of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Congenital Heart Surgeons\u2019 Society AVSD-TOF Working 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