{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:12:53Z","timestamp":1777878773571,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Review our clinical experience with eight patients at the University of Florida undergoing En-bloc combined heart+liver transplantation (ECH\u2009+\u2009LTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Continuous variables are reported as median (interquartile range\u2009=\u2009IQR) and categorical variables are reported as N (%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight patients underwent ECH\u2009+\u2009LTX between August 2020 and May 2023 at the University of Florida, with triple heart+liver+kidney transplantation performed in 2\/8\u2009=\u200925%. Median age at ECH\u2009+\u2009LTX was 47.34 years (IQR\u2009=\u200933.66-53.37), and all eight patients were &gt;18 years of age. Six out of eight patients (75%) had congenital heart disease (CHD): one had biventricular CHD and five had functionally univentricular circulation and Fontan failure. Two out of eight patients (25%) had structurally normal hearts and acquired heart disease: one patient with hemochromatosis and combined cardiac and hepatic failure with nonischemic restrictive cardiomyopathy and one patient with nonischemic cardiomyopathy and alcoholic cirrhosis. Median wait list time was 93 days (IQR\u2009=\u200927.50-176.25). Three patients (3\/8\u2009=\u200937.5%) were supported with an intra-aortic balloon pump prior to ECH\u2009+\u2009LTX, and two of these three patients were subsequently also supported with extracorporeal membrane oxygenation secondary to progressive decompensation prior to ECH\u2009+\u2009LTX. Median hospital length of stay was 147 days. Median posttransplant length of stay was of 29 days. Seven of eight patients survived ECH\u2009+\u2009LTX and are alive today. One patient died two days after ECH\u2009+\u2009LTX. Mean length of follow-up after ECH\u2009+\u2009LTX of seven surviving patients (years) is 3.60\u2009\u00b1\u20090.38 (median\u2009=\u20093.79, IQR\u2009=\u20093.05-4.38, range\u2009=\u20091.91-4.64).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>En-bloc heart-liver transplantation is an effective treatment option for patients with combined heart and liver failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351251338834","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T03:55:57Z","timestamp":1749441357000},"page":"106-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Single-Center Experience With En-Bloc Combined Heart+Liver Transplantation: Analysis of Eight Cases, Including Two Heart+Liver+Kidney Transplants"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-223X","authenticated-orcid":false,"given":"Matthew S.","family":"Purlee","sequence":"first","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Beduschi","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-929X","authenticated-orcid":false,"given":"Jeffrey Phillip","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werviston","family":"De Faria","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giles J.","family":"Peek","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5449-2114","authenticated-orcid":false,"given":"Ahmet","family":"Bilgili","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-4554","authenticated-orcid":false,"given":"Yuriy","family":"Stukov","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Steven","family":"Bleiweis","sequence":"additional","affiliation":[{"name":"Congenital Heart Center, Division of Cardiovascular Surgery, Departments of Surgery and Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14633"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045597"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-02002-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12892"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13870"},{"key":"e_1_3_2_7_2","article-title":"Combined en bloc heart and liver organ procurement","volume":"2024","author":"Stukov Y","year":"2024","unstructured":"Stukov Y, Bleiweis M, Faria W, Beduschi T, Peek GJ, Jacobs JP. Combined en bloc heart and liver organ procurement. Multimed Man Cardiothorac Surg. 2024;2024. doi:https:\/\/doi.org\/10.1510\/mmcts.2024.010. PMID: 38728012.","journal-title":"Multimed Man Cardiothorac Surg"},{"key":"e_1_3_2_8_2","article-title":"Combined en bloc heart and liver transplant","volume":"2024","author":"Stukov Y","year":"2024","unstructured":"Stukov Y, Beduschi T, Jacobs JP, et al. Combined en bloc heart and liver transplant. Multimed Man Cardiothorac Surg. 2024;2024. doi:https:\/\/doi.org\/10.1510\/mmcts.2024.110. 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