{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:13:04Z","timestamp":1777878784708,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A minority of patients with hypoplastic left heart syndrome (HLHS) are at extremely high risk for staged palliation and can be bridged-to-heart transplantation with bilateral pulmonary artery bands, ductal stenting, and single ventricle-ventricular assist device insertion (HYBRID\u2009+\u2009sVAD). The purpose of this analysis is to assess our learning curve associated with our first ten patients with functionally univentricular ductal-dependent systemic circulation who were supported with primary HYBRID\u2009+\u2009sVAD as bridge-to-heart transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were temporally separated into two cohorts: the first five and second five. Demographic, perioperative, and outcome data were collected. Continuous variables are described as median [IQR](range). Categorical variables are described as N (%).\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values were calculated using Fisher exact\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test for categorical variables and unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      tests for continuous variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten patients underwent HYBRID\u2009+\u2009sVAD operations for HLHS (2017-2022). Patients in the initial cohort and the most recent cohort were similar in age and weight. Liver dysfunction and renal dysfunction were more common in the first five patients (2\/5\u2009=\u200940%) versus the next five patients (0\/5\u2009=\u20090%). Length of sVAD support was longer in the most recent five patients (98 days [64-138] vs 154 days [134-225],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.08); however, no increase in sVAD-associated stroke or bleeding was seen in the most recent five patients. Despite very similar demographic and preoperative profiles, only two of the first five patients (2\/5\u2009=\u200940%) survived to heart transplantation, while all of the next 5 (5\/5\u2009=\u2009100%) were successfully bridged-to-cardiac transplantation with HYBRID\u2009+\u2009sVAD and are alive today.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our experience with primary HYBRID\u2009+\u2009sVAD as bridge-to-heart transplantation in neonates with HLHS demonstrates an important learning curve associated with this operation and approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351251360691","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:07:11Z","timestamp":1758722831000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Learning Curve is Associated With Combined Hybrid Procedure and Single Ventricle-Ventricular Assist Device Insertion in Neonates With Hypoplastic Left Heart Syndrome"],"prefix":"10.1177","volume":"17","author":[{"given":"Matthew S.","family":"Purlee","sequence":"first","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-929X","authenticated-orcid":false,"given":"Jeffrey Phillip","family":"Jacobs","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Philip","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Fudge","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himesh V.","family":"Vyas","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukumar Suguna","family":"Narasimhulu","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Cruz","family":"Beltran","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Pitkin","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Janelle","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-6498","authenticated-orcid":false,"given":"Giles J.","family":"Peek","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0009","authenticated-orcid":false,"given":"Mark Steven","family":"Bleiweis","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107001266"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000111"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.2279"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-022-01908-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000002211"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64433-5"},{"issue":"1","key":"e_1_3_3_8_2","first-page":"39","article-title":"\u201cCorrection\u201d de l'atr\u00e9sie tricuspidienne. Rapport de deux cas \u201ccorrig\u00e9s\u201d par l'utilisation d'une technique chirurgicale nouvelle [\u201ccorrection\u201d of tricuspid atresia. 2 cases \u201ccorrected\u201d using a new surgical technic]","volume":"10","author":"Fontan F","year":"1971","unstructured":"Fontan F, Mounicot FB, Baudet E, Simonneau J, Gordo J, Gouffrant JM. \u201cCorrection\u201d de l'atr\u00e9sie tricuspidienne. Rapport de deux cas \u201ccorrig\u00e9s\u201d par l'utilisation d'une technique chirurgicale nouvelle [\u201ccorrection\u201d of tricuspid atresia. 2 cases \u201ccorrected\u201d using a new surgical technic]. Ann Chir Thorac Cardiovasc. 1971;10(1):39\u201347. French. PMID: 5101717.","journal-title":"Ann Chir Thorac Cardiovasc"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90224-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S104795112100281X"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/21501351231189277"},{"issue":"24","key":"e_1_3_3_12_2","article-title":"Comprehensive approach to the management of patients with hypoplastic left heart syndrome: analysis of 100 consecutive neonates","author":"Bleiweis MS","year":"2024","unstructured":"Bleiweis MS, Co-Vu J, Philip J, et al. Comprehensive approach to the management of patients with hypoplastic left heart syndrome: analysis of 100 consecutive neonates. 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