{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:13:08Z","timestamp":1777878788539,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    In adult patients with transposition of the great arteries (TGA) and systemic right ventricle (sRV), the use of ventricular assist devices (VADs) is uncommon.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We conducted a systematic review of published studies to examine the indications, hemodynamic effects, and outcomes of VADs in this patient population. We reviewed English-language literature for case reports, case series, and reviews that included individual patient data, such as demographics, hemodynamic parameters, types of implanted VADs, and outcomes.\n                    <jats:bold>Results:<\/jats:bold>\n                    We identified 107 patients, 76% (81\/107) males, mean age 40.2\u2009\u00b1\u200910.6 at the time of implantation, 38.3% (41\/107) with left TGA (L-TGA), and 61.7% (66\/107) with dextro-TGA (D-TGA). The VAD support resulted in hemodynamic improvement, including a decrease in the mean pulmonary arterial pressure (45\u2009\u00b1\u200915 mm\u2009Hg before implantation to 25\u2009\u00b1\u20099.3 mm\u2009Hg afterwards,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), pulmonary vascular resistance (6.3\u2009\u00b1\u20094.9 Wood units (WU) to 2.4\u2009\u00b1\u20091.35 WU,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), right atrial pressure (16.4\u2009\u00b1\u20097.3 mm\u2009Hg to 9.5\u2009\u00b1\u20093.7 mm\u2009Hg,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.009), and pulmonary capillary wedge pressure (25.45\u2009\u00b1\u20097.12 mm\u2009Hg to 14.25\u2009\u00b1\u20095.6 mm\u2009Hg,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). The cardiac index increased from 2.0\u2009\u00b1\u20090.5 L\/min\/m\u00b2 to 2.8\u2009\u00b1\u20090.6 L\/min\/m\u00b2 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.004). The 1-year survival rate was 80.5%. Eventually, 31 (29%) underwent heart transplantation, and 48 (54%) remained on VAD at the time of publication.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Durable VADs provide hemodynamic improvement and excellent survival in adults with a systemic right ventricle. Expanding the use of VADs for this patient population would be justified.\n                  <\/jats:p>","DOI":"10.1177\/21501351251375987","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:46:42Z","timestamp":1760712402000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventricular Assist Devices in Adults With Transposition of the Great Arteries and Systemic Right Ventricle: Systematic Literature Review"],"prefix":"10.1177","volume":"17","author":[{"given":"Abdalla Eltayeb A.","family":"Abdelkader","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-3135","authenticated-orcid":false,"given":"Maya","family":"Guglin","sequence":"additional","affiliation":[{"name":"Indiana University School of 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