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Pathogenic variants in the LOX gene are associated with familial thoracic aortic aneurysms. A five-year-old male presented to the emergency room with upper respiratory tract symptoms. A chest radiograph showed a markedly enlarged mediastinum. Further studies revealed a 9-cm thoracic aortic aneurysm confined to the ascending aorta. The child underwent successful surgical intervention.<\/jats:p>","DOI":"10.1177\/21501351251404457","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:01:06Z","timestamp":1770040866000},"page":"681-683","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Familial Ascending Aortic Aneurysm in a Child With a Pathologic Variant of the Lysyl Oxidase Gene"],"prefix":"10.1177","volume":"17","author":[{"given":"Jose E. 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