{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:45:28Z","timestamp":1782564328568,"version":"3.54.5"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2025-GSP-GG-11"],"award-info":[{"award-number":["2025-GSP-GG-11"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-GSP-GG-19"],"award-info":[{"award-number":["2025-GSP-GG-19"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-GSP-QN-7"],"award-info":[{"award-number":["2025-GSP-QN-7"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>For pediatric patients with congenital heart disease (CHD) and pulmonary arterial hypertension (PAH), corrective repair carries a substantial risk of inducing pulmonary hypertensive crisis (PHC). The conventional clinical strategy involves postoperative administration of inhaled nitric oxide (iNO) followed by a gradual tapering process, which is often associated with prolonged postoperative recovery. To address this limitation, this study proposes a fast-weaning strategy: the continuation of iNO delivery via high-flow nasal cannula (HFNC) following extubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This single-center, retrospective cohort study screened pediatric patients with systemic-to-pulmonary artery shunt type CHD and a pulmonary vascular resistance index (PVRi)\u2009&gt;\u20096 WU\u2009\u00d7\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      between 2019 and 2024. Eligible patients admitted from 2023 to 2024 were assigned to Group 1 (fast-weaning), while those admitted from 2019 to 2022 constituted Group 2 (standard-weaning). For propensity-score matching, the predictive variables included age, preoperative PVRi, and the duration of cardiopulmonary bypass.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Following propensity score matching, 22 matched pairs were included in the final analysis. Pulmonary hypertensive crisis recurrence occurred in two of 22 patients (9.1%) in Group 1 and three of 22 patients (13.6%) in Group 2 (p\u2009&gt;\u20090.99). Patients in Group 1 had a significantly shorter duration of mechanical ventilation (18 [8.5, 22.3]) versus 21.5 (19.8, 27.3) hours; p\u2009=\u20090.014) and postoperative intensive care unit length of stay (2 [1, 4]) versus 3 [3, 5] days; p\u2009=\u20090.023). No major postoperative complications were reported in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Continuing iNO via HFNC following extubation is a safe weaning strategy. It may be associated with faster recovery, providing a potential alternative to conventional protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351261450515","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:24:31Z","timestamp":1782390271000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhaled Nitric Oxide via High-Flow Nasal Cannula in Postrepair Congenital Heart Disease Patients With Pulmonary Arterial Hypertension Following Extubation: A Cohort Study With Propensity Score Matching"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-0218","authenticated-orcid":false,"given":"Xiaofeng","family":"Wang","sequence":"first","affiliation":[{"name":"Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinnan","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gu","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.5334\/gh.831"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.02.1494"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/674885"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02187-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2021.08.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05093-w"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02122-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01324-2024"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-20-431"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.70389\/PJS.10081"},{"issue":"21","key":"e_1_3_2_13_2","first-page":"2037","article-title":"American Heart Association council on cardiopulmonary, critical care, perioperative and resuscitation; council on clinical cardiology; council on cardiovascular disease in the young; council on cardiovascular radiology and intervention; council on cardiovascular surgery and anesthesia; and the American thoracic society","volume":"132","author":"Abman SH","year":"2015","unstructured":"Abman SH, Hansmann G, Archer SL, et al. American Heart Association council on cardiopulmonary, critical care, perioperative and resuscitation; council on clinical cardiology; council on cardiovascular disease in the young; council on cardiovascular radiology and intervention; council on cardiovascular surgery and anesthesia; and the American thoracic society. Pediatr Pulmon Hypertens: Guidelines From the Am Heart Assoc Am Thorac Soc. Circulation. 2015;132(21):2037-2099.","journal-title":"Pediatr Pulmon Hypertens: Guidelines From the Am Heart Assoc Am Thorac Soc. Circulation"},{"issue":"7","key":"e_1_3_2_14_2","first-page":"1165","article-title":"Midterm results of \u201ctreat and repair\u201d for adults with non-restrictive ventricular septal defect and severe pulmonary hypertension","volume":"7","author":"Hu Z","year":"2015","unstructured":"Hu Z, Xie B, Zhai X, et al. Midterm results of \u201ctreat and repair\u201d for adults with non-restrictive ventricular septal defect and severe pulmonary hypertension. J Thorac Dis. 2015;7(7):1165-1173.","journal-title":"J Thorac Dis"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-023-01971-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12067"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202201-0199OC"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.104117"},{"issue":"6","key":"e_1_3_2_20_2","first-page":"409","article-title":"Inhaled nitric oxide therapy using high-flow nasal cannula in adults after open heart surgery","volume":"77","author":"Inoue N","year":"2024","unstructured":"Inoue N, Yamamoto N, Ohtomo Y, Ohtomo Y, Fukunishi T. Inhaled nitric oxide therapy using high-flow nasal cannula in adults after open heart surgery. 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